Summary
The absorption of talinolol (TA) 50 mg was investigated without and together with the co-administration of sulfasalazine (SASP) 4 g in 11 healthy young volunteers, in order to clarify gastrointestinal transit of TA.
Without SASP, the tmax of TA was 2.8 h, Cmax was 112 ng·ml−1 and the half life was 12 h; the AUCo-t was 958 ng·ml−1·h.
In the case of concomitant administration of SASP, TA was found only in serum from 3 individuals, with a Cmax of 23 ng·ml−1 and a mean AUCo-t of 84 ng·ml−1·h. TA was not detectable in 5 subjects and it was at the limit of detection (2 ng·ml−1) in 3 subjects. Pharmacokinetic analysis was not possible in any of those individuals.
The reason for the interaction appears to be the adsorption of TA by SASP. An interval of 2–3 h should elapse between giving SASP and other drugs.
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Terhaag, B., Palm, U., Sahre, H. et al. Interaction of talinolol and sulfasalazine in the human gastrointestinal tract. Eur J Clin Pharmacol 42, 461–462 (1992). https://doi.org/10.1007/BF00280137
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DOI: https://doi.org/10.1007/BF00280137