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Inhibition by basic drugs of digoxin secretion into human bile

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Summary

Bile samples from previous interaction studies in man were re-analysed by a combined HPLC/radioimmunoassay method. Quinidine, quinine and verapamil but not probenecid or spironolactone were found to inhibit the biliary secretion of unchanged digoxin.

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References

  1. Angelin B, Arvidsson A, Dahlqvist R, Hedman A, Schenck-Gustafsson K (1987) Quinidine reduces biliary clearance of digoxin in man. Eur J Clin Invest 17: 262–265

    Google Scholar 

  2. Hedman A, Angelin B, Arvidsson A, Dahlqvist R, Nilsson B (1990) Interactions in the renal and biliary elimination of digoxin: Stereoselective difference between quinine and quinidine. Clin Pharmacol Ther 47: 20–26

    Google Scholar 

  3. Hedman A, Angelin B, Arvidsson A, Beck O, Dahlqvist R, Nilsson B, Olsson M, Schenck-Gustafsson K (1991) Digoxin-verapamil interaction: reduction of biliary but not renal digoxin clearance in humans. Clin Pharmacol Ther 49: 256–262

    Google Scholar 

  4. Hedman A, Angelin B, Arvidsson A, Dahlqvist R (1991) No effect of probenecid on the renal and biliary clearances of digoxin in man. Br J Clin Pharmacol 32: 63–67

    Google Scholar 

  5. Hedman A, Angelin B, Arvidsson A, Dahlqvist R (1991 c) Digoxin-interactions in man. Spironolactone decreases renal but not biliary digoxin clearance. Eur J Clin Pharmacol (in publication)

  6. Marcus FI, Kapadia GJ, Kapadia GG (1964) The metabolism of digoxin in normal subjects. J Pharmacol Exp Ther 145: 203–209

    Google Scholar 

  7. Beermann B, Hellström K, Rosén A (1972) The absorption of orally administered (12 alpha-3H) digoxin in man. Clin Sci 43: 507–518

    Google Scholar 

  8. Caldwell JH, Cline CT (1976) Biliary excretion of digoxin in man. Clin Pharmacol Ther 19: 410–415

    Google Scholar 

  9. Gault MH, Sugden D, Maloney C, Ahmed M, Tweeddale M (1979) Biotransformation and elimination of digoxin with normal and minimal renal function. Clin Pharmacol Ther 25: 499–513

    Google Scholar 

  10. Schenck-Gustafsson K, Dahlqvist R (1981) Pharmacokinetics of digoxin in patients subjected to the quinidine-digoxin interaction. Br J Clin Pharmacology 11: 181–186

    Google Scholar 

  11. Magnusson JO, Bergdahl B, Bogentoft C, Jonsson UE, Tekenbergs L (1982) Excretion of digoxin and its metabolites in urine after a single oral dose in healthy subjects. Biopharm Drug Dispos 3: 211–218

    Google Scholar 

  12. Gault MH, Longerich LL, Loo JCK, Ko PTH, Fine A, Vasdev SC, Dawe MA (1984) Digoxin biotransformation. Clin Pharmacol Ther 35: 74–82

    Google Scholar 

  13. Gault MH, Longerich L, Dawe M, Vasdev SC (1985) Combined liquid chromatography/radioimmunoassay with improved specificity for serum digoxin. Clin Chem 31: 1272–1277

    Google Scholar 

  14. Stone JA, Soldin SJ (1988) Improved liquid chromatographic/immunoassay of digoxin in serum. Clin Chem 34/12: 2547–2551

    Google Scholar 

  15. Vetticaden SJ, Barr WH, Beightol LA (1986) Improved method for assaying digoxin in serum using high-performance liquid chromatography — radioimmunoassay. J Chromatogr 383: 187–193

    Google Scholar 

  16. Doherty JE, Flanigan WJ, Murphy ML, Bulloch RT, Dalrymple GL, Beard OW, Perkins WH (1970) Tritiated digoxin. XIV. Enterohepatic circulation, absorption, and excretion studies in human volunteers. Circulation 42: 867–873

    Google Scholar 

  17. Eaton DL, Klaassen CD (1978) Carrier-mediated transport of ouabain in isolated hepatocytes. J Pharmacol Exp Ther 205: 480–488

    Google Scholar 

  18. Sato J, Sawada Y, Iga T, Hanano M (1983) Effect of quinidine on digoxin distribution and elimination in guinea-pigs. J Pharm Sci 72: 1137–1141

    Google Scholar 

  19. Ben-Itzhak J, Bassan HM, Shor R, Lanir A (1985) Digoxin quinidine interaction: A pharmacokinetic study in the isolated perfused rat liver. Life Sci 37: 411–415

    Google Scholar 

  20. Okudaira K, Sawada Y, Sugiyama Y, Iga T, Hanano M (1988) Effects of basic drugs on the hepatic transport of cardiac glycosides in rats. Biochem Pharmacol 37: 2949–2955

    Google Scholar 

  21. Selye H, Krajny M, Savoie L (1969) Digitoxin poisoning: Prevention by spironolactone. Science 164: 842–843

    Google Scholar 

  22. Wirth KE, Frölich JC, Hollifield JW, Falkner FC, Sweetman BS, Oates JA (1976) Metabolism of digitoxin in man and its modification by spironolactone. Eur J Clin Pharmacol 9: 345–354

    Google Scholar 

  23. Wirth KE, Frölich JC (1974) Effect of spironolactone on excretion of 3H-digoxin and its metabolites in rats. Eur J Pharmacol 29: 43–51

    Google Scholar 

  24. Abshagen U, Rennekamp H, Kuhlmann J (1976) Effects of pretreatment with spironolactone on pharmacokinetics of 4‴-methyldigoxin in man. Naun Schmiedebergs Arch Pharmacol 292: 87–92

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden

    A. Hedman

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  1. A. Hedman
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Hedman, A. Inhibition by basic drugs of digoxin secretion into human bile. Eur J Clin Pharmacol 42, 457–459 (1992). https://doi.org/10.1007/BF00280136

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  • DOI: https://doi.org/10.1007/BF00280136

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