European Journal of Clinical Pharmacology

, Volume 42, Issue 4, pp 385–388 | Cite as

Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men

  • P. Monteleone
  • M. Maj
  • L. Beinat
  • M. Natale
  • D. Kemali


The effect of chronic administration of phosphatidylserine derived from brain cortex on the neuroendocrine responses to physical stress has been examined in a placebo-controlled study in 9 healthy men.

Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P=0.003 and P=0.03, respectively), without affecting the rise in plasma GH and PRL.

Physical exercise significantly increased the plasma lactate concentration both after placebo and phosphatidylserine.

The results suggest that chronic oral administration of phosphatidylserine may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis in man.

Key words

Phosphatidylserine Stress ACTH cortisol lactate growth hormone prolactin 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • P. Monteleone
    • 1
  • M. Maj
    • 1
  • L. Beinat
    • 2
  • M. Natale
    • 1
  • D. Kemali
    • 1
  1. 1.Institute of Psychiatry, First Medical schoolUniversity of NaplesNaplesItaly
  2. 2.Fidia Research LaboratoriesAbano Terme (Padova)Italy

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