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Alcohol hangover and Liv.52

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Summary

Ethanol and acetaldehyde levels in blood and urine have been evaluated in 9 volunteers following administration of Liv.52 and placebo on the evening of the study and on the following morning. On the following morning the volunteers scored their symptoms and completed visual analogue scales. Single dose and multiple dose studies were done.

Liv.52 produced a considerable reduction in blood and urine levels of ethanol and acetaldehyde after 12 h. It is possible that Liv.52 prevents the binding of acetaldehyde, bringing about higher initial blood levels followed by rapid elimination. It reduced the hangover symptoms.

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References

  1. Charles S, Lieber MD (1988) Biochemical and molecular basis of alcohol-induced injury to liver and other tissues. N Engl J Med 25: 1639–1650

    Google Scholar 

  2. Lelbach WK (1975) Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse. Ann NY Acad Sci 285: 85–105

    Google Scholar 

  3. Diluzio NB, Hartman AD (1967) Role of lipid peroxidation in the pathogenesis of ethanol-induced fatty liver. Fed Proc 26: 1436–1438

    Google Scholar 

  4. William J (1984) Liver disorders in alcoholism. In: Rosalki SB (ed) Clinical chemistry of alcoholism. Churchill Livingstone, New York, p 258–270

    Google Scholar 

  5. Chauhan BL, Kulkarni RD (1989) Effect of Liv.52, a herbal preparation, on absorption and metabolism of ethanol in humans. Eur J Clin Pharmacol

  6. Li TK (1977) Enzymology of human alcohol metabolism: In: Meister A (ed) Alcoholism. Churchill Livingstone, New York, p 19–56

    Google Scholar 

  7. Mendenhall CL, Macgee J, Green ES (1980) Simple, rapid and sensitive method for the simultaneous quantitation of ethanol and acetaldehyde in biological materials using Head Space Gas Chromatography. J Chromatogr 190: 197–200

    Google Scholar 

  8. Smith SC, Barnes GM (1983) Signs and symptoms of hangover; prevalence and relation to alcohol use in general population. Drug Alc Depend 11: 249–269

    Google Scholar 

  9. Ylikahri RH, Huttumen MD, Erikson CJP, Nikkila EA (1974) Metabolic studies on pathogenesis of hangover. Eur J Clin Invest 4: 93–100

    Google Scholar 

  10. Sorrell MF, Tuma DJ (1987) The functional implication of acetaldehyde binding to all constituents. In: Rubin E (ed) Alcohol and cells. NY Academy of Science, p 50–62

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Chauhan, B.L., Kulkarni, R.D. Alcohol hangover and Liv.52. Eur J Clin Pharmacol 40, 187–188 (1991). https://doi.org/10.1007/BF00280075

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  • DOI: https://doi.org/10.1007/BF00280075

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