Summary
In a study of 23 matched pairs of Type 1 (insulin-dependent) diabetic patients receiving continuous subcutaneous insulin infusion or conventional insulin injection therapy respectively, there were no significant differences in serum levels of the acute phase proteins, serum amyloid A and C-reactive protein. These results do not support the suggestion that continuous subcutaneous insulin infusion stimulates serum amyloid A production or that it carries a risk of inducing reactive systemic amyloidosis.
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Bending, J.J., Pickup, J.C., Rowe, I.F. et al. Continuous subcutaneous insulin infusion does not induce a significant acute phase response of serum amyloid A protein. Diabetologia 28, 113–115 (1985). https://doi.org/10.1007/BF00279927
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DOI: https://doi.org/10.1007/BF00279927