Summary
The presence of Fc-receptor-blocking factors in the sera of normal and insulin-dependent diabetic pregnant women was investigated by means of an antibody-dependent cellmediated cytotoxicity assay. Sera from normal pregnant women induced a significant depression of antibody dependent cell-mediated cytotoxicity when compared with sera from normal and diabetic non-pregnant women (p<0.0001; p<0.002, respectively). The effect of sera from diabetic pregnant women, however, was not different from that observed with sera from normal and diabetic non-pregnant women. Thus, we confirm the presence of Fc-receptor-blocking factors in the sera of normal pregnant women. The higher cytotoxicity levels measured in the presence of sera from pregnant women with insulin-dependent diabetes suggests that the titres of such factors are reduced in this condition.
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Zuccarini, O., Sensi, M., Gargiulo, P. et al. Sera from diabetic pregnant women contain reduced titres of inhibiting factors on killer cell activity. Diabetologia 28, 95–98 (1985). https://doi.org/10.1007/BF00279923
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DOI: https://doi.org/10.1007/BF00279923