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Dissociation of the lateral and medial cerebellum in movement timing and movement execution

Experimental Brain Research volume 73, pages 167–180 (1988)Cite this article

Summary

In a previous study (Ivry and Keele, in press), cerebellar patients were found to be impaired on both a motor and a perceptual task which required accurate timing. This report presents case study analyses of seven patients with focal lesions in the cerebellum. The lesions were predominantly in the lateral, hemispheric regions for four of the patients. For the remaining three patients, the lesions were centered near the medial zone of the cerebellum. The clinical evaluation of the patients also was in agreement with the different lesion foci: lateral lesions primarily impaired fine motor coordination, especially apparent in movements with the distal extremities and medial lesions primarily disturbed balance and gait. All of the patients were found to have increased variability in performing rhythmic tapping when tapping with an effector (finger or foot) ipsilateral to the lesion in comparison to their performance with a contralateral effector. Separable estimates of a central timekeeper component and an implementation component were derived from the total variability scores following a model developed by Wing and Kristofferson (1973). This analysis indicated that the poor performance of patients with lateral lesions can be attributed to a deficit in the central timing process. In contrast, patients with medial lesions are able to accurately determine when to make a response, but are unable to implement the response at the desired time. A similar dissociation between the lateral and medial regions has been observed on a time perception task in patients with cerebellar atrophy. It is concluded that the lateral regions of the cerebellum are critical for the accurate functioning of an internal timing system.

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References

  • Adams R, Victor M (1985) Principles of neurology. McGraw-Hill, New York

    Google Scholar 

  • Aitkin L, Boyd J (1975) Responses of single units in cerebellar vermis of the cat to monaural and binaural stimuli. J Neurophysiol 38: 418–429

    Google Scholar 

  • Allen G, Tsukahara N (1974) Cerebrocerebellar communications systems. Physiol Rev 54: 957–1006

    Google Scholar 

  • Allsop J, Turner B (1966) Cerebellar degeneration associated with chronic alcoholism. J Neurol Sci 3: 238–258

    Google Scholar 

  • Asanuma C, Thach W, Jones E (1983a) Distribution of cerebellar terminations and their relation to other afferent terminations in the ventral lateral thalamic region of the monkey. Brain Res Rev 5: 237–265

    Google Scholar 

  • Asanuma C, Thach W, Jones E (1983b) Anatomical evidence for segregated focal groupings of efferent cells and their ramifications in the cerebellothalamic pathway of the monkey. Brain Res Rev 5: 267–298

    Google Scholar 

  • Asanuma C, Thach W, Jones E (1983c) Brainstem and spinal projections of the deep cerebellar nuclei in the monkey with observations on the brainstem projections of the dorsal column nuclei. Brain Res Rev 5: 299–322

    Google Scholar 

  • Bava A, Grimm R, Rushmer D (1983) Fastigial unit activity during voluntary movement in primates. Brain Res 288: 371–374

    Google Scholar 

  • Braitenberg V (1967) Is the cerebellar cortex a biological clock in the millisecond range? Prog Brain Res 25: 334–346

    Google Scholar 

  • Brooks V, Thach W (1981) Cerebellar control of posture and movement. In: Brooks V (ed) Handbook of physiology. Motor control. American Physiology Society, Washington, DC, pp 877–946

    Google Scholar 

  • Conrad B, Brooks V (1974) Effects of dentate cooling on rapid alternating arm movements. J Physiol (Lond) 37: 792–804

    Google Scholar 

  • Dichgans J, Diener H (1984) Clinical evidence for functional compartmentalization of the cerebellum. In: Bloedel J, Dichgans J, Precht W (eds) Cerebellar functions. Springer, Berlin Heidelberg New York, pp 126–147

    Google Scholar 

  • Eccles J (1977) Cerebellar function in the control of movement. In: Rose F (ed) Physiological aspects of clinical neurology. Blackwell, Oxford, pp 157–178

    Google Scholar 

  • Flumerfelt B, Otabe S, Courville J (1973) Distinct projections to the red nucleus from the dentate and interposed nuclei in the monkey. Brain Res 50: 408–414

    Google Scholar 

  • Greenfield J (1958) System degenerations of the cerebellum, brain stem, and spinal cord. In: Greenfield J, Blackwood W, McMenemey W, Meyer A, Norman R (eds) Neuropathology. Edward Arnold, London, pp 529–549

    Google Scholar 

  • Hall J (1976) Classical conditioning and instrumental learning: a contemporary approach. Lippincott, Philadelphia

    Google Scholar 

  • Hallett M, Shahani B, Young R (1975) EMG analysis of patients with cerebellar deficits. J Neurol Neurosurg Psychiatry 38: 1163–1169

    Google Scholar 

  • Holmes G (1939) The cerebellum of man. Brain 62: 1–30

    Google Scholar 

  • Ivry R (1986) Components of coordinations: the cerebellum as an internal clock. Doctoral dissertation. University of Oregon, Eugene

    Google Scholar 

  • Ivry R, Keele S (in press) Timing functions of the cerebellum. Cognitive Neuroscience

  • Ivry R, Keele S (1985) Dissociation of the central timekeeper and the peripheral implementation processes in repetitive movements. University of Oregon Cognitive Science Technical Report 85-7

  • Ito M (1984) The cerebellum and neural control. Raven Press, New York

    Google Scholar 

  • Keele S, Ivry R (1987) Modular analysis of timing in motor skill. In: Bower G (ed) Psychology of learning and motivation. Academic Press, New York, pp 183–228

    Google Scholar 

  • Keele S, Manchester D, Rafal R (1985a) Is the cerebelum involved in motor and perceptual timing: a case study. University of Oregon Cognitive Science Technical Report 85-4, Eugene

  • Keels S, Pokorny R, Corcos D, Ivry R (1985b) Do perception and motor production share common timing mechanisms: a correlational analysis. Acta Psychol (Amst) 60: 173–191

    Google Scholar 

  • Kelso J, Scholz J (1985) Cooperative phenomena in biological motion. In: Haken J (ed) Synergetics of complex systems in physics, chemistry and biology. Springer, Berlin Heidelberg New York, pp 124–149

    Google Scholar 

  • Kemp J, Powell T (1971) The connexions of the striatum and globus pallidus: synthesis and speculation. Philos Trans R Soc Lond (Biol) 262: 441–457

    Google Scholar 

  • Klapp S (1979) Doing two things at once: the role of temporal compatibility. Mem Cognit 7: 375–381

    Google Scholar 

  • Konigsmark B, Weiner L (1970) The olivopontocerebellar atrophies: a review. Medicine (Baltimore) 49: 227–241

    Google Scholar 

  • Leiner H, Leiner A, Dow R (1986) Does the cerebellum contribute to mental skills? Behav Neurosci 100: 443–454

    Google Scholar 

  • McCormick D, Thompson R (1984) Cerebellum: essential involvement in the classically conditioned eyelid response. Science 223: 296–299

    Google Scholar 

  • Moyer K (1980) Neuroanatomy. Harper and Row, New York

    Google Scholar 

  • Musiek F, Baran J (1986) Neuroanatomy, neurophysiology, and central auditory assessment, Part I. Brain stem. Ear Hear 7: 207–219

    Google Scholar 

  • Pansky B, Allen D (eds) (1980) Review of neuroscience. MacMillan, New York

    Google Scholar 

  • Sasaki K (1984) Cerebro-cerebellar interactions and organization of a fast and stable hand movement: cerebellar participation in voluntary movement and motor learning. In: Bloedel J, Dichgans J, Precht W (eds) Cerebellar functions. Springer, Berlin Heidelberg New York, pp 70–85

    Google Scholar 

  • Schwartz A, Ebner T, Bloedel J (1987) Responses of interposed and dentate neurons to pertubations of the locomotor cycle. Exp Brain Res 67: 323–338

    Google Scholar 

  • Schell G, Strick P (1984) The origin of thalamic inputs to the arcuate premotor and supplementary motor areas. J Neurosci 4: 539–560

    Google Scholar 

  • Terzuolo C, Soechting J, Viviani P (1973) Studies on the control of some simple motor tasks. II. On the cerebellar control of movements in relation to the formation to the formulation of intentional commands. Brain Res 58: 217–222

    Google Scholar 

  • Thach W (1970) Discharge of cerebellar neurons related to two maintained postures and two prompt movements. I. Nuclear cell ouptut. J Neurophysiol 33: 527–536

    Google Scholar 

  • Thach W (1975) Timing of activity in cerebellar dentate nucleus and cerebral motor cortex during prompt volitional movement. Brain Res 88: 233–241

    Google Scholar 

  • Thach W (1978) Correlation of neural discharge with pattern and force of muscular activity, joint position, and direction of the intended movement in motor cortex and cerebellum. J Neurophysiol 41: 654–676

    Google Scholar 

  • Thompson R, Clark G, Donegan N, Lavond D, Madden J, Mamounas L, Mauk M, McCormick D (1984) Neuronal substrates of basic associative learning. In: Squire L, Butters N (eds) Neuropsychology of memory. Guilford Press, New York, pp 424–442

    Google Scholar 

  • Vilis T, Hore J (1980) Central neural mechanisms contributing to cerebellar tremor produced by limb perturbations. J Neurophysiol 43: 279–291

    Google Scholar 

  • Wilson V, Uchino Y, Maunz R, Susswein A, Fukushima K (1978) Properties and connections of cat fastigiospinal neurons. Exp Brain Res 32: 1–17

    Google Scholar 

  • Wing A (1977) Effects of type of movement on the temporal precision of respone sequences. Br J Math Stat Psychol 30: 60–72

    Google Scholar 

  • Wing A (1980) The long and short of timing in response sequences. In: Stelmach G, Requin J (eds) Tutorials in motor behavior. North-Holland, New York

    Google Scholar 

  • Wing A, Kristofferson A (1973) Response delays and the timing of discrete motor responses. Percept Psychophys 14: 5–12

    Google Scholar 

  • Yammamoto T, Hassler R, Huber C, Wagner A, Sasaki K (1983) Electrophysiologic studies on the pallido- and cerebellothalamic projections in squirrel monkeys. Exp Brain Res 51: 77–87

    Google Scholar 

  • Yamanishi J, Kawato M, Suzuki R (1980) Two coupled oscillators as a model for the coordinated finger tapping by both hands. Biol Cybern 37: 219–225

    Google Scholar 

  • Yeo C, Hardiman M, Glickstein M (1985) Classical conditioning of the nictitating membrane response of the rabbit. II. Lesions of the cerebellar cortex. Exp Brain Res 60: 99–113

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychology, University of Oregon, 97403, Eugene, OR, USA

    R. B. Ivry & S. W. Keele

  2. Cognitive Neuropsychology Laboratory, Suite 460, Neurological Sciences Center, Good Samaritan Hospital, 97210, Portland, OR, USA

    R. B. Ivry

  3. Department of Neurology, University of Tübingen, D-7400, Tübingen, FRG

    H. C. Diener

Authors
  1. R. B. Ivry
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  2. S. W. Keele
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  3. H. C. Diener
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Ivry, R.B., Keele, S.W. & Diener, H.C. Dissociation of the lateral and medial cerebellum in movement timing and movement execution. Exp Brain Res 73, 167–180 (1988). https://doi.org/10.1007/BF00279670

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  • DOI: https://doi.org/10.1007/BF00279670

Key words

  • Cerebellum
  • Movement control
  • Timing
  • Movement execution