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The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus

Molecular and General Genetics MGG volume 238, pages 33–37 (1993)Cite this article

Abstract

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

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Author notes

  1. Charles R. Dearolf

    Present address: Dana Farber Cancer Institute, Room JF 209, 44 Binney Street, 02115, Boston, MA, USA

Authors and Affiliations

  1. Department of Biological Sciences, University of Southern Mississippi, 39406, Hattiesburg, MS, USA

    William P. Hanratty

  2. Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, 02115, Boston, MA, USA

    Charles R. Dearolf

Authors
  1. William P. Hanratty
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  2. Charles R. Dearolf
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Communicated by B.H. Judd

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Hanratty, W.P., Dearolf, C.R. The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Molec. Gen. Genet. 238, 33–37 (1993). https://doi.org/10.1007/BF00279527

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  • DOI: https://doi.org/10.1007/BF00279527

Key words

  • Drosophila melanogaster
  • Tumorous-lethal gene
  • hopscotch gene
  • Hematopoiesis