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Molecular and General Genetics MGG

, Volume 238, Issue 1–2, pp 33–37 | Cite as

The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus

  • William P. Hanratty
  • Charles R. Dearolf
Original Articles
  • 173 Downloads

Abstract

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

Key words

Drosophila melanogaster Tumorous-lethal gene hopscotch gene Hematopoiesis 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • William P. Hanratty
    • 1
  • Charles R. Dearolf
    • 2
  1. 1.Department of Biological SciencesUniversity of Southern MississippiHattiesburgUSA
  2. 2.Department of Radiation Oncology, Harvard Medical SchoolDana Farber Cancer InstituteBostonUSA

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