Abstract
The authors desribe a highly significant association between the AB0 blood group system and rheumatic carditis in Budapest samples (770 patients, 3830 controls). Persons belonging to blood group AB or A are more susceptible to this disease than others, while groups B and 0 are relatively protected. The influence of AB0-locus on the disease can be estimated as being of the order of 1/2% by the relative risk x=1.376 and a 2% incidence. The evaluation of studies published so far proved only the relative protection of group 0 against rheumatic fever; it seems probable that of persons suffering from rheumatic fever especially those of group A are more susceptible to develop carditis. The hypothesis is discussed that the relative protection of the blood group 0 and of the secretor phenotype against rheumatic fever could be based on the partial identity of the determinant groups of the human H-antigen —which is found in abundance in the body fluids of all secretors-and of the C-substance of the group A Streptococcus, which inhibits the allergic reaction.
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Direktor: Dr. Gy. Bodrogi
Direktor: Prof. Dr. M. Malán
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Zih, S., Thoma, A. AB0-Blutgruppen bei rheumatischem Fieber und rheumatischer Karditis. Hum Genet 4, 42–51 (1967). https://doi.org/10.1007/BF00279178
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DOI: https://doi.org/10.1007/BF00279178