Summary
The chromosomal localization of a unique DNA fragment, closely linked to Hintington disease (HD), was assessed in situ by hybridization with 2-acetylaminofluorene (AAF) modified probes. In these experiments, a cosmid cloned genomic fragment (c5.5) was used for hybridization. Here we present evidence that confirms the mapping of the D4S10 locus to the p16 region of chromosome 4 and assigns it to the telomere of the short arm.
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Landegent, J.E., Jansen in de Wal, N., Fisser-Groen, Y.M. et al. Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization. Hum Genet 73, 354–357 (1986). https://doi.org/10.1007/BF00279100
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DOI: https://doi.org/10.1007/BF00279100