Summary
Close genetic linkage has been shown between the DNA sequence G8 (locus D4S10) and 16 British families with Huntington disease using the HindIII, EcoR1, Nci1, and Pst1 polymorphisms detected by G8, and by combining all the polymorphisms to give a combined haplotype. Two recombinants have been detected in these families giving a maximum lod score of 17.60 at a Θ of 0.02. These results confirm the originally reported linkage between the loci and provide evidence against significant multilocus heterogeneity for Huntington disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Folstein SE, Phillips JA, Meyers DA, Chase GA, Abbott MH, Franz ML, Waber PG, Kazazian HH, Conneally PM, Hobbs W, Tanzi R, Faryniarz A, Gibbons K, Gusella JF (1985) Huntington's discase: two families with differing clinical features show linkage to the G8 probe. Science 229:776–779
Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, Young AB, Shoulson I, Bonilla E, Martin JB (1983) A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306:234–238
Gusella JF, Tanzi RE, Anderson MA, Hobbs W, Gibbons K, Rashtchian R, Gilliam TC, Wallace MR, Wexler NS, Conneally PM (1984a) DNA markers of nervous system diseases. Science 225: 1320–1326
Gusella JF, Gibbons K, Hobbs W, Heft R, Anderson M, Rashtchian R, Folsten S, Wallace P, Conneally PM, Tanzi R (1984b) The G8 locus linked to Huntington's disease. Am J Hum Genet 36: 139S
Gusella JF, Tanzi RE, Bader PI, Phelan MC, Stevenson R, Hayden MR, Hofman KJ, Faryniaz AG, Gibbon K (1985) Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome. Nature 318:75–78
Harper PS, Sarfarazi M (1985) Genetic prediction and family structure in Huntington's chorea. Br Med J 290:1929–1931
Harper PS, Youngman S, Anderson MA, Sarfarazi M, Quarrell Q, Tanzi R, Shaw D, Wallace P, Conneally PM, Gusclla JF (1985) Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families. J Med Genet 22:447–450
Kidd KK, Gusella JF (1985) Report of the committee on the genetic constitution of chromosomes 3 and 4. (Human Gene Mapping 8.) Cytogenet Cell Genet 40:107–127
Kunkel LM, Smith KD, Boyer SH, Borgaonkar DS, Watchel SS, Miller OJ, Breg WR, Jones HW Jr, Rary JM (1977) Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants. Proc Natl Acad Sci USA 74:1245–1249
Lathrop GM, Lalouel JM, Julier C, Ott J (1984) Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81: 3443–3446
Newcombe RG (1981) A life table for onset of Huntington's chorea. Ann Hum Genet 45:375–383
Ott J (1974) Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet 26:588–597
Walker DA, Harper PS, Wells CGC, Tyler A, Davies K, Newcombe RG (1981) Huntington's chorea in South Wales. A genetic and epidemiological study. Clin Genet 19:213–221
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Youngman, S., Sarfarazi, M., Quarrell, O.W.J. et al. Studies of a DNA marker (G8) genetically linked to Huntington disease in British families. Hum Genet 73, 333–339 (1986). https://doi.org/10.1007/BF00279096
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00279096