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Acute myeloid leukemia with two philadelphia chromosomes in forty-six stemline

Remarks on the karyotypic analysis and chemotherapy

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Summary

Serial cytogenetic studies of bone marrow in a 59-year-old male with a 14-month history of acute myeloid leukemia revealed a Ph1 disomic diploid clone (46, XY, 2Ph1). This clone responded to a cytostatic drug regimen of prednisone, vincristine and daunomycine. A dual population of normal and leukemic cells was observed during the course the disease.

Zusammenfassung

Bei einem 59 Jahre alten Mann mit akuter Myeloblastenleukämie, von 14monatigem Verlauf, fand sich im Knochenmark ein Doppel-Ph1 diploider Clone (46, XY, 2Ph1). Dieser Clone war empfindlich gegenüber einer Prednison-, Vincristin- und Daunomycin-Kombination. Eine Dualpopulation normaler und leukämischer Zellen wurde während des Verlaufes beobachtet.

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Authors and Affiliations

  1. Abteilung für Hämatologie, Zentrum der Inneren Medizin der Johann Wolfgang Goethe-Universität, Frankfurt a. Main, Germany

    M. Hussein Khan

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  1. M. Hussein Khan
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Additional information

Dedicated to Prof. Dr. Sajiro Makino, Faculty of Science, Hokkaido University, Sapporo, Japan.

Supported by the Deutsche Forschungsgemeinschaft, Bad Godesberg.

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Khan, M.H. Acute myeloid leukemia with two philadelphia chromosomes in forty-six stemline. Hum Genet 18, 55–62 (1973). https://doi.org/10.1007/BF00279031

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  • DOI: https://doi.org/10.1007/BF00279031

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