Summary
Three mouse genomic domains, Fim1, Fim2, and Fim3, were previously described as proviral integration regions frequently involved in the early stages of myeloblastic leukemogenesis induced in vivo or in vitro by the Friend murine leukemia virus. Fim2 was identified as the 5′ end of the c-Fms, protooncogene, which encodes the receptor of the macrophage colony stimulating factor (Csflr). The functions of Fim1 and Fim3 are not yet known, but these regions are highly conserved among different species. To examine whether these regions could correspond to known human loci involved in genetic alterations specific to some human leukemias, we undertook their chromosomal mapping. The localization of FIM2/c-FMS on 5q33 was confirmed. FIM1 and FIM3 were localized on human chromosomes 6p22.3–p23 and 3q27 respectively. Interestingly, translocations involving these two regions have been described in various hematopoietic malignancies: the t(6;9)(p23;q34) in acute nonlymphocytic leukemias and the 3q26–q28 translocations in a large variety of leukemias.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Adriaansen HJ, Van Dongen JJM, Hooijkaas H, Hählen K, Van't Veer MB, Löwenberg B, Hagemeijer A (1988) Translocation (6;9) may be associated with a specific TdT-positive immunological phenotype in ANNL. Leukemia 2:136–140
Bloomfield CD, Trent JM, Berghe H van den (1987) Report of the committee on structural chromosome changes in neoplasia. (9th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 46:344–356
Bordereaux D, Fichelson S, Sola B, Tambourin PE, Gisselbrecht S (1987) Frequent involvement of the fim-3 region in F-MuLV-induced mouse myeloblastic leukemias. J Virol 61:4043–4045
Camargo M, Cervenka J (1982) Patterns of DNA replication of human chromosomes. II. Replication map and replication model. Am J Hum Genet 34:757–780
Creagan R, Tischfield J, Riccuiti F, Ruddle FH (1973) Chromosome assignment of genes in man using mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol oxidase B, tetrametric) to chromosome 6. Humangenetik 20:203–209
Dutrillaux B, Lejeune J (1971) Sur une nouvelle technique d'analyse du caryotype human. C R Acad Sci Ser D 272:2638–2640
Eladari ME, Syed SH, Guilhot S, d'Auriol L, Galibert F (1986) On the high conservation of the human c-myc first exon. Biochem Biophys Res Commun 140:313–319
Fichelson S, Sola B, Dreyfus F, Bordereaux D, Gisselbrecht S, Tambourin P (1988) Early involvement of the fim-2 and fim-3 regions in mouse myeloblastic leukemogenesis. Leukemia (in press)
Gisselbrecht S, Fichelson S, Sola B, Bordereaux D, Hampe A, André C, Galibert F, Tambourin PE (1987) Frequent c-fms activation by proviral insertion in mouse myeloblastic leukaemias. Nature 329: 259–261
Froffen J, Heisterkamp N, Spurr N, Dana S, Wasmuth JJ, Stephenson JR (1983) Chromosomal localization of the human c-fms oncogene. Nucleic Acids Res 11:6331–6339
Heard JM, Fichelson S, Sola B, Martial MA, Berger R, Varet B, Levy JP (1983) Malignant myeloblastic transformation of murine long-term bone marrow cultures by F-MuLV: in vitro reproduction of a long-term leukemogenesis, and investigation of preleukemic events. Int J Cancer 32:237–245
Human Gene Mapping 9 (1987) Paris Conference. (9th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 46: 1–762
ISCN (1981) An international system for human cytogenetic nomenclature. High-resolution banding. Report of the standing committee on human cytogenetic nomenclature. Cytogenet Cell Genet 31:1–32
Lalley PA, O'Brien SJ, Créau-Goldberg N, Davisson MT, Roderick TH, Echard G, Womack JE, Graves JM, Doolittle DP, Guidi JN (1987) Report of the committee on comparative mapping. (9th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 46:367–389
Le Beau MM, Westbrook CA, Diaz MO, Larson RA, Rowley JD, Gasson JC, Golde DW, Sherr CJ (1986) Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders. Science 231:984–987
Mattei MG, Philip N, Passage E, Moisan JL, Mattei JF (1985) DNA probe localization at 18p13 band by in situ hybridization and identification of a small supernumerary chromosome. Hum Genet 69: 268–271
Mendelsohn ML, Mayall BH, Bogart E, Moore DH, Perry BH (1973) DNA content and DNA-based centrometric index of the 24 human chromosomes. Science 179:1126–1129
Naylor SL, Shows TB, Klebe RJ (1979) Bio-autographic visualization of aminoacylase-1: assignment of the structural gene ACYL-1 to chromosome 3 in man. Somatic Cell Genet 5:11–21
Nguyen VC, Weil D, Finaz C, Cohen-Haguenauer O, Gross MS, Jégou-Foubert C, Tand MF de, Cochet C, Grouchy J de, Frézal J (1986) Panel of twenty-five independent man-rodent hybrids for human genetic marker mapping. Ann Génét (Paris) 29:20–26
Nguyen VC, Fichelson S, Sola B, Gross MS, Jégou-Foubert C, Bordereaux D, Gisselbrecht S, Tambourin P, Frézal J (1987) Assignment of Fim-2 (CSF1R) to chromosome 5q33 (in situ hybridization) and Fim-3 to chromosome 3 (somatic cell analysis) region 3q27 (in situ hybridization). (9th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 46:670 (abstr)
Nusse R (1986) The activation of cellular oncogenes by retroviral infection. Trends Genet 2:244–247
Pettenati MJ, Le Beau MM, Lemons RS, Shima EA, Kawasaki ES, Larson RA, Sherr CJ, Diaz MO, Rowley JD (1987) Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. Proc Natl Acad Sci USA 84:2970–2974
Qavi H, Kit S (1980) Electrophoretic patterns of aminoacylase-1 (ACY-1) isozymes in vertebrate cells and histochemical procedure for detecting ACY-1 activity. Biochem Genet 18:669–679
Roussel MF, Sherr CJ, Barker PE, Ruddle FH (1983) Molecular cloning of the c-fms locus and its assignment to human chromosome 5. J Virol 48:770–773
Sola B, Fichelson S, Bordereaux D, Tambourin PE, Gisselbrecht S (1986) fim-1 and fim-2: two new integration regions of Friend murine leukemia virus in myeloblastic leukemias. J Virol 60:718–725
Sola B, Simon D, Mattei MG, Fichelson S, Bordereaux D, Tambourin PE, Guénet JL, Gisselbrecht S (1988) fim-1, fim-2/c-fms, fim-3 three common integration sites of F-MuLV in myeloblastic leukemias map to mouse chromosomes 13, 18 and 3 respectively. J Virol 62:3973–3978
Van Someren H, Beijersbergen Van Henegouven H, Los W, Warzer-Figarelli E, Doppert B, Vervloet M, Meera Khan P (1974) Enzyme electrophoresis on cellulose acetate gel: zymogram patterns in man-Chinese hamster somatic cell hybrids. Humangenetik 25: 189–201
Zabel BU, Naylor SL, Sakaguchi AY, Bell GI, Shows TB (1983) High-resolution chromosomal localization of human genes for amylase, propeomelanocortin, somatostatin and a DNA fragment (D3S1) by in situ hybridization. Proc Natl Acad Sci USA 80: 6932–6936
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nguyen Van Cong, Fichelson, S., Gross, M.S. et al. The human homologues of Fim1, Fim2/c-Fms, and Fim3, three retroviral integration regions involved in mouse myeloblastic leukemias, are respectively located on chromosomes 6p23, 5q33, and 3q27. Hum Genet 81, 257–263 (1989). https://doi.org/10.1007/BF00279000
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00279000