Summary
We have recently demonstrated tight linkage of the Duffy blood group marker to the α-spectrin gene in an extended pedigree with Charcot-Marie-Tooth neuropathy. To determine a more precise location of the Duffy blood group locus on the chromosome 1 map we have tested several more chromosome 1 genes for linkage with this marker. We found suggestive linkage with the antithrombin III and apolipoprotein A2 genes and conclusive linkage with the gene coding for β-nerve growth factor.
Similar content being viewed by others
References
Bird TD, Ott J, Giblett ER (1982) Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1. Am J Hum Genet 34:388–394
Breakefield XO, Orloff G, Castiglione C, Coussens L, Axerlrod FB, Ullrich A (1984) Structural gene for β-nerve growth factor not defective in familial dysautonomia. Proc Natl Acad Sci USA 81: 4213–4216
Chance PF, Murray JC, Bird TD, Kochin RS (1987) Genetic linkage relationships of Charcot-Marie-Tooth disease (HMSN-Ib) to chromosome 1 markers. Neurology 37:325–329
Cook PJL, Page BM, Johnston AW, Stanford WK, Gavin J (1978) Four further families informative for 1q and the Duffy blood group. Cytogenet Cell Genet 22:378–380
Cosgriff TM, Bishop DT, Hershgold EJ, Skolnick MH, Martin BA, Baty BJ, Carlson KS (1983) Familial antithrombin III deficiency: its natural history, genetics, diagnosis and treatment. Medicine 62:209–220
Cutbush M, Mollison PL, Parkin DM (1950) A new human blood group. Nature 165:188–189
Darby JK, Feder J, Selby M, Riccardi V, Ferrell R, Siao D, Goslin K, Rutter W, Shooter EM, Cavalli-Sforza LL (1985a) A discordant sibship analysis between β-NGF and neurofibromatosis. Am J Hum Genet 37:52–59
Darby JK, Kidd JR, Pakstis AJ, Sparkes RS, Cann HM, Ferrell RE, Gerhard DG, Riccardi V, Egeland JA, Shooter EM, Cavalli-Sforza LL, Kidd KK (1985b) Linkage relationships of the gene for the β subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci. Cytogenet Cell Genet 39:158–160
Darby JK, Johnson J, Nakashima P, Willems PJ, O'Brien JS, Fowler ML, Shows TB, Shooter EM, Cavalli-Sforza LL (1986) PvuII RFLP at the human chromosome 1 α-l-fucosidase gene locus FUCA1. Nucleic Acids Res 14:9543
Donahue RP, Bias WB, Renwick JH, McKusick VA (1968) Probable assignment of the Duffy blood group locus to chromosome 1 in man. Proc Natl Acad Sci USA 61:949–955
Dyck PJ, Ott J, Moore SB, Swanson CJ, Lambert EH (1983) Linkage evidence for genetic heterogeneity among kinships with hereditary motor and sensory neuropathy, type I. Mayo Clin Proc 58: 430–435
Frossard PM, Gonzalez PA, Dillan NA, Coleman RT, Atlas SA (1986a) Human renin (REN) gene locus: BglII, RsaI and TaqI RFLPs. Nucleic Acids Res 14:6778
Frossard PM, Gonzalez PA, Fritz LC, Ponte PA, Fiddes JC, Atlas SA (1986b) Two RFLPs at the human renin (REN) gene locus. Nucleic Acids Res 14:4380
Griffiths LR, Zwi MB, McLeod JG, Nicholson GA (1988) Chromosome 1 linkage studies in Charcot-Marie-Tooth neuropathy type 1. Am J Hum Genet 42:756–771
Guiloff RJ, Thomas PK, Contreras M, Armitage S, Schwarz G, Sedgwick EM (1982) Evidence for linkage of type I hereditary motor and sensory neuropathy to the Duffy locus on chromosome 1. Ann Hum Genet 46:25–27
Huebner K, Palumbo AP, Isobe M, Kozak CA, Monaco S, Rovera G, Croce CM, Curtis PJ (1985) The α-spectrin gene is on chromosome 1 in mouse and man. Proc Natl Acad Sci USA 82:3790–3793
Ionasescu V, Murray JF, Burns TL, Ionasescu R, Ferrell R, Searby C, Chirgwin J (1987) Linkage analysis of Charcot-Marie-Tooth neuropathy (HMSN type I). J Neurol Sci 80:73–78
Lathrop GM, Lalouel JM, Julier C, Ott J (1985) Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am J Hum Genet 37:482–498
Morton NE, Bruns GA (1987) Report of the committee on the genetic constitution of chromosomes 1 and 2. Cytogenet Cell Genet 46: 102–118
Pakstis AJ, Kidd JR, Castiglione CM, Hawley ME, Wu J-S, Kidd KK (1987) Large sex differences significantly revise the linkage map for part of chromosome 1. Am J Hum Genet 41:180A
Prochownik EV, Antonarakis S, Bauer KA, Rosenberg RD, Fearon ER, Orkin SH (1983) Molecular heterogeneity of inherited antithrombin III deficiency. N Engl J Med 308:1549–1552
Race RR, Sanger R (1975) Blood groups in man, 6th edn. Blackwell, Oxford, pp 350–363
Raeymaekers P, Van Broekhoven C, Backhovens H, De Jonghe P, Gheuens J, Muylle L, Wehnert A, Vandenberghe A (1987) Duffy blood group and α-spectrin map to the same region on chromosome 1. Cytogenet Cell Genet 46:678
Raeymackers P, Van Broeckhoven C, Backhovens H, Wehnert A, Muylle L, De Jonghe P, Gheuens J, Vandenberghe A (1988a) The Duffy blood group is linked to the α-spectrin locus in a large pedigree with autosomal dominant inheritance of Charcot-Marie-Tooth type 1. Hum Genet 78:76–78
Raeymaekers P, De Jonghe P, Swerts L, Muylle L, Gheuens J, Martin J-J, Van Broeckhoven C, Vandenberghe A (1988b) Absence of linkage with the Duffy blood group in a family with Charcot-Marie-Tooth neuropathy. J Neurol Sci (in press)
Scott J, Knott TJ, Priestley LM, Robertson ME, Mann DV, Kostner G, Miller GJ, Miller NE (1985) High-density lipoprotein composition is altered by a common DNA polymorphism adjacent to apoprotein AII gene in man. Lancet I:771–773
Stebbins NB, Conneally PM (1982) Linkage of dominantly inherited Charcot-Marie-Tooth neuropathy to the Duffy locus in an Indiana family. Am J Hum Genet 34: 195A
Weiss MJ, Spielman RS, Harris H (1987) A high-frequency RFLP at the human liver/bone/kidney type alkaline phosphatase locus. Nucleic Acids Res 15:860
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Raeymaekers, P., Van Broeckhoven, C., Backhovens, H. et al. Linkage analysis of the Duffy blood group marker with several chromosome 1 genes in an extended pedigree with Charcot-Marie-Tooth disease. Hum Genet 81, 231–233 (1989). https://doi.org/10.1007/BF00278994
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00278994