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Sister chromatid exchanges and aging

III. The Effect of Donor Age on Mutagen-Induced Sister Chromatid Exchange in Human Diploid Fibroblasts

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Summary

Although baseline levels of SCE appear to be similar in metaphase cells derived from young and old human skin fibroblast cultures, as significant decline in both MMC- and AAAF-induced sister chromatid exchanges was observed in the older cell populations. Considerable variation exists in the levels of MMC-induced SCE between individual cell cultures. However, parallel examination of several cell strains from young and old donors confirmed the decrease in mutagen-induced SCE frequencies in older cell populations.

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Authors and Affiliations

  1. Section on Cellular Aging and Genetics, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, PHS, U.S. Department of Health, Education and Welfare, 21224, Baltimore, MD, USA

    Edward L. Schneider & Brian Gilman

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  1. Edward L. Schneider
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  2. Brian Gilman
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Schneider, E.L., Gilman, B. Sister chromatid exchanges and aging. Hum Genet 46, 57–63 (1979). https://doi.org/10.1007/BF00278902

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  • DOI: https://doi.org/10.1007/BF00278902

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