Summary
The family of an individual was studied who lacks the seventh component of complement in his serum (C7 homozygous deficiency). Both parents are C7 heterozygousdeficient. In this investigation, the following parameters were determined: complement components in functional and immunochemical tests; HLA-A,B antigens, HLA-D (MLC) determinants; the Bf system; glyoxalase I and B cell antigens. No evidence for linkage between the immunogenetic linkage group on chromosome 6 and gene(s) controlling the synthesis of the seventh component of complement was obtained. This is in accordance with the assumption that only genes controlling components of the initiating rather than the membrane attack unit of complement are linked to the HLA region.
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Grosse-Wilde, H., Netzel, B., Mempel, W., Ruppelt, W., Brehm, G., Bertrams, J., Ewald, R., Lenhard, V., Rittner, Ch., Scholz, S., Albert, E. D.: Immunogenetics of LD determinants in man. Histocompatibility testing, F. Kissmeyer-Nielsen, ed., p. 526. Copenhagen: Munksgaard 1975
Hannema, A. J., Pondman, K. W., Döhmann, U., Gadner, H., Dorren, I. J.: C7 deficiency in man. In: Protides of the biological fluids, H. Peeters, ed. Oxford: Pergamon 1975
Kömpf, J., Bissbort, S., Gussmann, S., Ritter, H.: Polymorphism of red cell glyoxalase I (E.C. 4.4.1.5.). A new genetic marker in man. Humangenetik 27, 141–143 (1975)
Martin, W.: Personal communication
Mayr, W. R., Mayr, D., Kömpf, J., Bissbort, S., Ritter, H.: Possible linkage of HL-A and GLO. Humangenetik 31, 241–242 (1976)
Müller-Eberhard, H. J.: Patterns of complement activation. In: Progress in immunology II, Vol. 1, L. Brent and J. Holborow, eds. Amsterdam: North Holland 1974
Pretorius, A. M. G., Scholz, S., Kuntz, B., Albert, E. D.: Investigations of the red cell glyoxalase (GLO) in recombinant families. Europ. J. Immunol. (in press)
Rittner, Ch.: Genetic loci of components of the classical and alternate pathway of complement activation: A new dimension of the immunogenetic linkage group (HLA) on chromosome No. 6 in man. Hum. Genet. (in press)
Rittner, Ch., et al.: Data on the linkage group HLA-GLO-PGM3. In preparation
Rittner, Ch., Grosse-Wilde, H., Rittner, B., Netzel, B., Scholz, S., Lorenz, H., Albert, E. D.: Linkage group HL-A-MLC-Bf (properdin factor B). Humangenetik 27, 173–183 (1975a)
Rittner, Ch., Hauptmann, G., Grosse-Wilde, H., Grosshans, E., Tongio, M. M., Mayer, S.: Linkage between HL-A (Major Histocompatibility Complex) and genes controlling the synthesis of the fourth component of complement. Histocompatibility testing, F. Kissmeyer-Nielsen, ed., p. 945. Copenhagen: Munksgaard 1975b
Weitkamp, L. R.: Linkage of GLO with HLA and Bf. Effect of population and sex on recombination frequency. Tissue Antigens 7, 273 (1976)
Wellek, B., Opferkuch, W.: A case of deficiency of the seventh component of complement in man. Clin. exp. Immunol. 19, 223 (1975)
Wernet, P.: Human Ia-type alloantigens: Methods of detection, aspects of chemistry and biology, markers for disease states. Transplant. Rev. 30, 271 (1976)
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Rittner, C., Opferkuch, W., Wellek, B. et al. Lack of linkage between gene(s) controlling the synthesis of the seventh component of complement and the HLA region on chromosome No. 6 in man. Hum. Genet. 34, 137–142 (1976). https://doi.org/10.1007/BF00278881
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DOI: https://doi.org/10.1007/BF00278881