Summary
We analyzed chromosome preparations obtained from leukocytes of ten children with pyknolepsy and treated with dipropylacetate (DPA) as monotherapy. Structural or numerical aberrations were not found more frequently in our patients than in five normal children (control group).
References
Annegers, J. F., Elveback, L. R., Hauser, W. A., Kurland, L. T.: Do anticonvulsants have a teratogenic effect? Arch. Neurol. 31, 364–373 (1974)
Ayraud, N., Kermarec, J., Martinon, J.: Effects cytogénétiques des médicaments anticonvulsivants. Ann. Genet. (Paris) 11, 253–257 (1968)
Bartsch, H. D.: Cytogenetic testing of antiepileptic drugs in human patients (Abstr.). Mutat. Res. 29, 279 (1975)
Dudin, G., Beek, B., Obe, G.: The human leucocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures. Mutat. Res. 23, 279–281 (1974)
Eymard, P.: Ergenyl: Pharmakologische und teratologische Gesichtspunkte. Intern. Arbeitstagung, Frankfurt 27.4.1974
Faust, J., Vogel, W., Löning, B.: A case with 46,XX,del(11)(q21). Clin. Genet. 6, 90–97 (1974)
Große, K.-P., Schwanitz, G., Rott, H.-D., Wißmüller, H. F.: Chromosomenuntersuchungen bei Behandlung mit Anticonvulsiva. Hum. Genet. 16, 209–216 (1972)
Hanson, J. W., Smith, D. W.: The fetal hydantoin syndrome. J. Pediatr. 87, 285–290 (1975)
Herha, J., Obe, G.: Chromosomal damage in epileptics on monotherapy. Hum. Genet. 34, 255–263 (1976)
Janz, D.: Teratologische Wirkungen von Antiepileptika. In: Antiepileptische Langzeitmedikation, pharmakokinetik-klinische Begleitwirkungen, H. Helmchen, L. Diehl, eds. Bibl. Psychiatr. 151, 86–98 (1975)
Neuhäuser, G., Schwanitz, G., Rott, H.-D.: Zur Frage mutagener und teratogener Wirkung von Antikonvulsiva. Fortschr. Med. 88, 819–820 (1970)
Obe, G., Herha, J.: Chromosomal damage in chronic alcohol users. Hum. Genet. 29, 191–200 (1975)
Obe, G., Beek, B., Dudin, G.: The human leucocyte test system. V. DNA synthesis and mitoses in PHA-stimulated 3-day cultures. Hum. Genet. 28, 295–302 (1975)
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Kotlarek, F., Faust, J. Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy. Hum Genet 43, 329–331 (1978). https://doi.org/10.1007/BF00278841
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DOI: https://doi.org/10.1007/BF00278841