Skip to main content
Log in

Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy

  • Short Communications
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

We analyzed chromosome preparations obtained from leukocytes of ten children with pyknolepsy and treated with dipropylacetate (DPA) as monotherapy. Structural or numerical aberrations were not found more frequently in our patients than in five normal children (control group).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Annegers, J. F., Elveback, L. R., Hauser, W. A., Kurland, L. T.: Do anticonvulsants have a teratogenic effect? Arch. Neurol. 31, 364–373 (1974)

    Google Scholar 

  • Ayraud, N., Kermarec, J., Martinon, J.: Effects cytogénétiques des médicaments anticonvulsivants. Ann. Genet. (Paris) 11, 253–257 (1968)

    Google Scholar 

  • Bartsch, H. D.: Cytogenetic testing of antiepileptic drugs in human patients (Abstr.). Mutat. Res. 29, 279 (1975)

    Google Scholar 

  • Dudin, G., Beek, B., Obe, G.: The human leucocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures. Mutat. Res. 23, 279–281 (1974)

    Google Scholar 

  • Eymard, P.: Ergenyl: Pharmakologische und teratologische Gesichtspunkte. Intern. Arbeitstagung, Frankfurt 27.4.1974

  • Faust, J., Vogel, W., Löning, B.: A case with 46,XX,del(11)(q21). Clin. Genet. 6, 90–97 (1974)

    Google Scholar 

  • Große, K.-P., Schwanitz, G., Rott, H.-D., Wißmüller, H. F.: Chromosomenuntersuchungen bei Behandlung mit Anticonvulsiva. Hum. Genet. 16, 209–216 (1972)

    Google Scholar 

  • Hanson, J. W., Smith, D. W.: The fetal hydantoin syndrome. J. Pediatr. 87, 285–290 (1975)

    Google Scholar 

  • Herha, J., Obe, G.: Chromosomal damage in epileptics on monotherapy. Hum. Genet. 34, 255–263 (1976)

    Google Scholar 

  • Janz, D.: Teratologische Wirkungen von Antiepileptika. In: Antiepileptische Langzeitmedikation, pharmakokinetik-klinische Begleitwirkungen, H. Helmchen, L. Diehl, eds. Bibl. Psychiatr. 151, 86–98 (1975)

  • Neuhäuser, G., Schwanitz, G., Rott, H.-D.: Zur Frage mutagener und teratogener Wirkung von Antikonvulsiva. Fortschr. Med. 88, 819–820 (1970)

    Google Scholar 

  • Obe, G., Herha, J.: Chromosomal damage in chronic alcohol users. Hum. Genet. 29, 191–200 (1975)

    Google Scholar 

  • Obe, G., Beek, B., Dudin, G.: The human leucocyte test system. V. DNA synthesis and mitoses in PHA-stimulated 3-day cultures. Hum. Genet. 28, 295–302 (1975)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kotlarek, F., Faust, J. Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy. Hum Genet 43, 329–331 (1978). https://doi.org/10.1007/BF00278841

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00278841

Keywords

Navigation