Summary
The dynamics of some mutational events were studied in a Siberian town with a chemical industry. Retro-and prospective evaluations of the frequency of spontaneous abortions, multiple congenital malformations, and Down syndrome were carried out. Mutational components of these end-points were summarized and provisionally termed “units of mutational events” (UME). The results show that the frequencies of UME have not changed in 14 years.
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References
Altukhov YuP (1980) Environmental conditions and genetic monitoring of populations. In: Vartanian ME (ed) Well-being of mankind and genetics. Proc. XIV Cong. Genet., vol 1 book 1. Mir Publishers, Moscow, pp 238–256
Bochkov NP (1977) Genetic monitoring of human populations in connection with the environment pollution. Cytol Genet 3:195–206
Bochkov NP (1984) Medical aspects of genetic monitoring. Vestn Akad Med Nauk SSSR 7:3–6
Chebotarev AN, Bochkov NP, Kirichenko OP (1973) Population-cytogenetical studies of newborns with congenital malformations. Genetika (Moskva) 9:146–158
Emery AEH, Rimoin DL (eds) (1983) Principles and practice of medical genetics. Churchill Livingstone, Edinburgh
Hook EB (1981) Prevalence of chromosome abnormalities during human gestation and implication for studies of environmental mutagens. Lancet II:169–172
Kuleshov NP (1976) Chromosome anomalies of infants dying during the perinatal period and premature newborns. Hum Genet 3:151–160
Lauritsen JG (1977) Genetic aspects of spontaneous abortion. Dan Med Bull 24:169–189
Morton NE, Hassold TJ, Funkhouser J, McKenna PW, Lew R (1982) Cytogenetic surveillance of spontaneous abortions. Cytogenet Cell Genet 33:232–239
Neel JV (1974) Developments in monitoring human populations for mutation rates. Mutat Res 26:319–328
Neel JV (1980) Some considerations pertinent to monitoring human populations for changing mutation rates. In: Vartanian ME (ed) Well-being of mankind and genetics. Proc. XIV Cong. Genet., vol 1, book 1. Mir Publishers, Moscow, pp 225–238
Soltan HG, Craven JL (1981) The extent of genetic disease in hospital populations. Can Med Assoc J 124:427–429
Vogel F (1970) Monitoring of human populations. In: Vogel F, Röhrborn G (eds) Chemical mutagenesis in mammals and man. Springer, Berlin, pp 445–452
Vogel F (1975) Spontaneous mutation in man. Adv Hum Genet 5:223–318
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Bochkov, N.P., Grigorian, S.D., Lunga, I.N. et al. Retro-and prospective evaluation of dynamics of some mutational events. Hum Genet 72, 77–79 (1986). https://doi.org/10.1007/BF00278822
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DOI: https://doi.org/10.1007/BF00278822