Skip to main content
Log in

Fluctuation of a clone 46,XX,i(7q) in bone marrow in a Fanconi anaemia

  • Short Communications
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

A 10-year-old Fanconi anaemia patient showed a 46,XX/46,XX,-7,+i(7q) constitution in bone marrow which disappeared without any specific treatment and then reappeared during a year of survey. We discuss i(7q) and Fanconi anaemia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Arthur DC, Bloomfield CD, Lindquist LL, Nesbit ME (1982) Translocation 4;11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance. Blood 59:96–99

    Google Scholar 

  • Ayraud N, Lambert JL, Hufferman-Tribollet K, Basteris B (1977) Etude cytogénétique comparative de 7 carcinomes d'origine mammaire. Ann Génét (Paris) 20:171–177

    Google Scholar 

  • Berger R, Bussel A, Schenmetzler C (1975) Anomalies chromosomiques et anémie de Fanconi. Etude de 4 cas. Nouv Rev Fr Hematol 15:539–550

    Google Scholar 

  • Berger R, Bussel A, Schenmetzler C (1977) Somatic segregation and Fanconi anemia. Clin Genet 11:409–415

    Google Scholar 

  • Berger R, Bernheim A, Leconiat M, Vecchione D, Schaison G (1980) Chromosomal studies of leukemic and preleukemic Fanconi's anemia patients. Hum Genet 56:59–62

    Google Scholar 

  • Bourgeois LA, Hill DFH (1977) Fanconi anemia leading to acute myelomonocytic leukemia. Cytogenetic studies. Cancer 39:1163–1167

    Google Scholar 

  • Chitambar LR, Robinson WA, Glode LM (1983) Familial leukemia and aplastic anemia associated with monosomy 7. Am J Med 75:756–762

    Google Scholar 

  • Crossen PE, Mellor JEL, Adams AL, Gunz FW (1972) Chromosome studies in Fanconi's anaemia before and after treatment with oxymetholone. Pathology 4:27–33

    Google Scholar 

  • Girard P, Leonard C, Quillard J, Eydoux P, Dael P, Dommergues JP, Tchernia G (1985) Myelofibrosis, myeloproliferative syndrome, and monosomy C in children. Eur Paediatr Haematol Oncol 2:13–21

    Google Scholar 

  • Hirschman RJ, Shulman NR, Abnelo JG, Whang-Peng J (1969) Chromosome aberrations in two cases of inherited aplastic anemia with unusual clinical features. Ann Intern Med 71:107–117

    Google Scholar 

  • Kaneko Y, Abe R, Sampi K, Sakurai M (1982a) An analysis of chromosome findings in Non-Hodgkin's lymphomas. Cancer Genet Cytogenet 5:107–121

    Google Scholar 

  • Kaneko Y, Variakojis D, Kluskens L, Rowley JD (1982b) Lymphoblastic lymphoma: cytogenetic, pathologic, and immunologic studies. Int J Cancer 30:273–279

    Google Scholar 

  • Kusnetsova LE, Prigogina EL, Pogosianz HE, Belkina BM (1982) Similar chromosomal abnormalities in several retinoblastomas. Hum Genet 61:201–204

    Google Scholar 

  • Lai JL, Jouet JP, Zandecki M, Huart JJ, Bauters F, Deminatti M (1983) Leucemie aigue lymphoblastique de type Burkitt. Fréquence et aspects cytogénétiques. Nouv Rev Fr Hematol 25:303–309

    Google Scholar 

  • Lisker R, Cobo de Gutierrez A (1974) Cytogenetic studies in Fanconi's anemia. Description of a case with bone marrow clonal evolution. Clin Genet 5:72–76

    Google Scholar 

  • Mark J, Ekedahl C, Dahlenfors R (1978) Characteristics of the patterns in non-Hodgkin and non-Burkitt lymphomas. Hereditas 80:229–242

    Google Scholar 

  • Mattina T, Sorge G, Pavone L, Russo A, Minniti C, Schiliro G (1985) B-cell acute lymphoblastic leukemia and isochromosome 7q. Leuk Res 9:497–499

    Google Scholar 

  • Meisner LF, Taher A, Shahidi NT (1978) Chromosome change and leukemic transformation in Fanconi's anemia. In: Hibino S (ed) Aplastic anemia. University Park Press, Baltimore, pp 253–271

    Google Scholar 

  • Morse HG, Heideman R, Hays T, Robinson A (1982) 4;11 translocation in acute lymphoblastic leukemia: a specific syndrome. Cancer Genet Cytogenet 7:165–172

    Google Scholar 

  • Nowell P, Bergman G, Besa E, Wilmoth D, Emanuel B (1984) Progressive preleukemia with a chromosomally abnormal clone in a kindred with the Estren-Dameshek variant of Fanconi's anemia. Blood 64:1135–1138

    Google Scholar 

  • Oshimura M, Freeman AI, Sandberg AA (1977) Chromosomes and causation of human cancer and leukemia. XXVI. Banding studies in acute lymphoblastic leukemia (ALL). Cancer 40:1161–1172

    Google Scholar 

  • Parkin JL, Arthur DC, Abramson CS, Mekenna RW, Korsey JH, Heideman RL, Brunning RD (1982) Acute leukemia associated with the t(4;11) chromosome rearrangement: ultrastructural and immunologic characteristics. Blood 60:1321–1331

    Google Scholar 

  • Perona G, Letto GL, Bernardi F, Todeschini G, D'Andrea F (1977) Fanconi's anaemia in adults: study of three families. Haematologica (Pavia) 62:615–628

    Google Scholar 

  • Roozendal KJ, Nelis KOAH (1984) Leukaemia in a case of Fanconi's anaemia. Clin Genet 25:208

    Google Scholar 

  • Sarna G, Tomasulo P, Lotz MJ, Bubinak JF, Shulman NR (1975) Multiple neoplasms in two siblings with a variant form of Fanconi's anemia. Cancer 36:1029–1033

    Google Scholar 

  • Schroeder TM, Drings P, Beilner P, Buchinger G (1977) Clinical and cytogenetic observations during a six year period in an adult with Fanconi's anaemia. Blut 34:119–132

    Google Scholar 

  • Stivrins TJ, Davis RB, Sanger W, Fritz J, Purtilo DJ (1984) Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7. Blood 64:173–176

    Google Scholar 

  • Tanzer J, Frocrain C, Desmaret MC (1980) Anomalies du chromosome 1 dans 3 cas de leucémie compliquant une aplasie de Fanconi (FA). Nouv Rev Fr Hematol 22:XC III

    Google Scholar 

  • Tanzer J, Frocrain C, Desmaret MC, Potiron M (1981) Fragilité chromosomique révélée seulement par culture en présence de moutarde à l'azote dans 2 cas de Maladies de Fanconi. Nouv Rev Fr Hematol 23:XVI

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Huret, J.L., Benz, E., Guilhot, F. et al. Fluctuation of a clone 46,XX,i(7q) in bone marrow in a Fanconi anaemia. Hum Genet 74, 98–100 (1986). https://doi.org/10.1007/BF00278794

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00278794

Keywords

Navigation