Summary
In five healthy family members of three generations a reciprocal translocation, t(6;12)(q27;q21), combined with an inverted insertion inv ins (7;8)(p14;q22q13), has been demonstrated. Neither offspring with unbalanced karyotypes nor descendants with isolated translocations or insertions were observed. Five simultaneously occurring chromosomal breaks are considered to be the reason for the new rearrangement.
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Meer, B., Wolff, G. & Back, E. Segregation of a complex rearrangement of chromosomes 6, 7, 8, and 12 through three generations. Hum Genet 58, 221–225 (1981). https://doi.org/10.1007/BF00278717
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DOI: https://doi.org/10.1007/BF00278717