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Isoelectric focusing of Gc (vitamin D binding globulin) in parentage testing

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Summary

Gc subtyping with isoelectric focusing (IEF) in paternity cases allowed us to increase the exclusion probability (P) of Gc in Whites to 31% from a (P) of 16% using agarose electrophoresis. Both IEF and agarose are necessary to identify certain rare variants, therefore it is recommended that both techniques be performed in cases of disputed parentage and population studies.

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Authors and Affiliations

  1. Minneapolis War Memorial Blood Bank, 2304 Park Avenue South, 55404, Minneapolis, MN, USA

    Dale Dykes, Herbert Polesky & Edmundo Cox

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  1. Dale Dykes
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  2. Herbert Polesky
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  3. Edmundo Cox
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Dykes, D., Polesky, H. & Cox, E. Isoelectric focusing of Gc (vitamin D binding globulin) in parentage testing. Hum Genet 58, 174–175 (1981). https://doi.org/10.1007/BF00278705

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  • DOI: https://doi.org/10.1007/BF00278705

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