Zur formalen Genetik von Isoenzymen, dargestellt am Beispiel der 6-PGD (EC: 1.1.1.44)

Summary

The results obtained in all animals examined for 6-PGD so far, indicate that this enzyme is a dimer molecule. In lower vertebrates, dimer molecules consist of identical subunits (=only a single locus). The majority of vertebrates possess 6-PGD isoenzymes composed of non identical subunits; thus, at least two loci are presumed. In homozygotes, three electrophoretic bands are seen when random association occurs. In individuals heterozygous for one locus six different electrophoretic bands are to be expected of which up to six have been identified. Thus, it is suggested that the formal notation should be for homozygous phenotypes: 6-PGD AB; for phenotypes heterozygous for one locus e.g.: 6-PGD AA¹B. A corresponding notation for other isoenzyme systems is possible on the presumption that the quarternary structure and formal genetics is known.