Summary
The genetic behaviour of a human serum β-lipoprotein factor, called Ag(a1), was studied by agar micro-diffusion technique, utilizing an antibody detected in the serum from a transfused thalassemia patient. It behaves as an inherited, dominant, autosomal character, with complete penetrance at birth. It is controlled by a gene \(Ag^{a_1 } \) and is closely linked to the Ag x and Ag y genes.
The existence of a gene Ag b, allelic to \(Ag^{a_1 } \), is postulated but the Ag(b) antigen has not so far been detected by specific antisera.
The frequency of the \(Ag^{a_1 } \) gene in a Milan population was found to be 0,43, and in a Berne population was 0,46. The frequencies of the four possible gene combinations in the sample group from Milan were: Ag yb=0,53; \(Ag^{ya_1 } \)=0,22; \(Ag^{xa_1 } \)=0,21; Ag xb=0,04.
The observed frequencies of the factor Ag(a1) were 0,676 and 0,713, respectively among the Milan and Berne populations.
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Morganti, G., Beolchini, P.E., Bütler, R. et al. Contribution to the genetics of serum β-lipoproteins in man. Hum Genet 5, 98–106 (1968). https://doi.org/10.1007/BF00278670
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DOI: https://doi.org/10.1007/BF00278670