Summary
The placental phosphoglucomutase phenotypes controlled by the first locus of 235 German and 119 non-German samples were determined. Both in the pooled material and in the sample containing German subjects only there was a significant deviation from the expected Hardy-Weinberg equilibrium. A segregation analysis of 1174 families also revealed significant deviations in the phenotypes of the children, though the mating frequencies were as expected. The distribution of the children's phenotypes deviated significantly from Hardy-Weinberg equilibrium though this was not found in the parent samples. The results are discussed.
Zusammenfassung
Placenta-Phosphoglucomutase-Phänotypen des ersten Locus wurden an Hand von 235 deutschen und 119 ausländischen Stichproben bestimmt. Sowohl das Gesamtmaterial als auch die deutsche Stichprobe allein zeigten eine signifikante Abweichung vom angenommenen Hardy-Weinberg-Gleichgewicht. Eine Aufspaltungsanalyse bei 1174 Familien ergab ebenfalls eine signifikante Abweichung bei den Phänotypen der Kinder, obgleich die Elternkombinationshäufigkeiten der Erwartung entsprachen. Die Verteilung der Kinderphänotypen wich signifikant vom Hardy-Weinberg-Gleichgewicht ab, während die Verteilung der Elternphänotypen mit den Erwartungswerten übereinstimmte. Die Ergebnisse werden diskutiert.
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Ananthakrishnan, R., Beck, W. & Walter, H. Is the PGM1 locus subject to selection?. Hum Genet 19, 247–252 (1973). https://doi.org/10.1007/BF00278397
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DOI: https://doi.org/10.1007/BF00278397