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Cytogenetic investigation of spontaneous abortions

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Summary

88 spontaneous abortions were investigated cytogenetically, 18 of them proved to have anomalies of chromosomes. Cells with aberrations were exposed to continuous cultivation. Successful prolonged cultures were grown from embryos with the following karyotypes: trisomy D, trisomy C and mosaicism (46,XX/47,XX,C+/48,XX,C+E+). It was shown that nonmosaic abnormal karyotypes were stable in the process of prolonged cultivation.

Zusammenfassung

88 spontane Aborte wurden cytogenetisch untersucht. Bei 18 von ihnen fanden sich Chromosomenanomalien. Bei Zellen und Aberrationen wurden Langzeit-Kulturen durchgeführt. Diese Langzeit-Kulturen waren erfolgreich bei Embryonen und den folgenden Karyotypen: Trisomie D, Trisomie C und einem Mosaik (46,XX/47,XX,C+/48,XX,C+E+). Abnorme Karyotypen ohne Mosaik verhielten sich bei der Langzeit-Kultivierung stabil.

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References

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Authors and Affiliations

  1. Laboratory of Cytogenetics of Institute of Human Morphology AMS USSR, Moscow

    A. M. Kuliev

  2. Biological Department of Azerbaijan State Medical Institute after N. Narimanov, Baku

    A. M. Kuliev

  3. The Institute of Medical Genetics AMS, Baltiyskaya St. 8, A-315, Moscow, USSR

    A. M. Kuliev

Authors
  1. A. M. Kuliev
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Kuliev, A.M. Cytogenetic investigation of spontaneous abortions. Hum Genet 12, 275–283 (1971). https://doi.org/10.1007/BF00278048

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  • DOI: https://doi.org/10.1007/BF00278048

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