Abstract
High-grade chondrosarcoma in the skull base has been known to be extremely refractory to adjuvant therapy. We report successful chemoradiation therapy for skull base chondrosarcoma in a child. The patient was a 6-year-old boy with an invasive skull base tumor. In spite of gross total removal of the tumor, it recurred 1 month after surgery. Following an intraarterial injection of adriamycin (10 mg), the second gross total removal was carried out. At the end of the operation, cisplatin (20 mg) was locally injected into the surgical cavity. The patient was further given a total of six courses of systemic chemotherapy in combination with adriamycin (30 mg/m2) and cisplatin (100 mg/m2) and 55 Gy focal irradiation. One year after the most recent surgery, the patient is in complete remission. The efficacy of adjuvant therapy of this rare tumor is discussed.
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References
Dirix LY, Van Oosterom AT (1991) Chondrosarcoma and other rare bone sarcomas. Curr Opin Oncol 3:694–699
Evans HL, Ayala AG, Romsdahl MM (1977) Prognostic factors in chondrosarcoma of bone. Cancer 40:818–831
Finn DG, Goepfelt H, Batsakis JG (1984) Chondrosarcoma of the head and neck. Laryngoscope 94:1539–1544
Fu YS, Perzin KH (1974) Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. Cancer 34:453–463
Grossman RI, Davis KR (1981) Cranial computed tomographic appearance of chondrosarcoma of the base of the skull. Neuroradiology 141:403–408
Harwood AR, Krajbich JI, Fornasier VL (1980) Radiotherapy of chondrosarcoma of bone. Cancer 45:2769–2777
Kobayashi T, Yoshida J, Kageyama N, Makita Y, Aoyama I, Yamashita S (1980) Mesenchymal chondrosarcoma arising from dura mater (in Japanese). Noshinkei Geka 8:881–887
Koga H, Lokukawa J, Miyagi K, Kaneshiro T, Harakuni T (1991) A case of chondrosarcoma in the cavernous sinus (in Japanese). Noshinkei Geka 19:1167–1170
Kveton JF, Brackmann DE, Grasscosk ME, House WF, Hitselberger WE (1986) Chondrosarcoma of the skull base. Otolaryngol Head Neck Surg 94:23–32
Masuzawa T, Nakahara N, Saito K, Sato F (1986) Parasellar chondrosarcoma. Neurol Med Chir (Tokyo) 26:44–48
Meyer SP, Hirsch WL, Curtin HD, Barnes L, Sekhar LN, Sen C (1992) Chondrosarcoma of the skull base. Radiology 184:103–108
Pritchard DJ, Lunke RJ, Taylor WF, Dahlin DC, Medley BE (1980) Chondrosarcoma: a clinicopathologic and statistical analysis. Cancer 45:149–157
Reichman B, Markman M, Hakes T, Hoskins W, Rubin S, Jones W, Almadrones L, Ochoa M, Chapman D, Saigo P, Lewis JL (1989) Intraperitoneal cisplatin and etoposide in the treatment of refractory/recurrent ovarian carcinoma. J Clin Oncol 7:1327–1332
Rosen G (1986) Neoadjuvant chemotherapy for osteogenic sarcoma. Recent Results Cancer Res 103:148–157
Seidman MD, Nichols RD, Raju UB, Mehta B, Levy HG (1989) Extracranial skull base chondrosarcoma. Ear Nose Throat J 68:626–635
Sen CN, Sekhar LN, Schramm VL, Janecka IP (1989) Chondroma and chondrosarcoma of the cranial base: an 8-year experience. Neurosurgery 25:931–941
Suit HD, Goitein M, Munzenrider J, Verhey L, Davis KR, Koehler A, Linggood R, Ojemann RG (1982) Definitive radiation therapy for chondroma and chondrosarcoma of base of skull and cervical spine. J Neurosurg 56:377–385
Welkerling H, Dreyer T, Delling G (1991) Morpholigical typing of chondrosarcoma: a study of 94 cases. Virchows Arch [A] 418:419–425
Zimm S, Cleary SM, Lucas WE, Weiss RJ, Markman M, Andrews PA, Schiefer MA, Kim S, Horton C, Howell SB (1987) Phase 1 pharmacokinetic surgery of intraperitoneal cisplatin and etoposide. Cancer Res 6:1712–1716
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Yoshimoto, T., Sawamura, Y., Ikeda, J. et al. Successful chemoradiation therapy for high-grade skull base chondrosarcoma in a child. Child's Nerv Syst 11, 250–253 (1995). https://doi.org/10.1007/BF00277662
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DOI: https://doi.org/10.1007/BF00277662