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Aspects of evaluation, significance, and evolution of human C-band heteromorphism

Human Genetics volume 61, pages 281–294 (1982)Cite this article

Summary

The C-band heteromorphism may be evaluated in different forms. The results obtained from classification are easily influenced by subjective factors, and the conclusions of such types of data are acceptable only if they are well matched with a control. The length measurements is simple to obtain, and a quantitative presentation of the data, with correction for the contraction stage of the chromosomes, is considered the most effecient method to evaluate the C-band size heteromorphism. Excluding the acrocentrics, whose short arms present a complex heteromorphism, and the chromosome Y, whose variable C band is terminal, all others present C-band location heteromorphism except pair 16. It is possible to multiply the detectable heteromorphisms in some bands by using diverse staining methods. The present state of knowledge about the role of heterochromatin in the cell is analyzed, as is the effect of C-band variability on the phenotype, the reproductive fitness, and the individual viability. Although a great amount of data is available, no result can be considered definitive as yet. Aspects in which the use of C-band heteromorphisms are profitable are considered.

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  1. B. Erdtmann

    Present address: Institu für Anthropologie und Humangenetik, Universität Heidelberg, Im Neuenheimer Feld 328, D-6900, Heidelberg, Federal Republic of Germany

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  1. Departmento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Caixa postal 1953, 90000, Porto Alegre, RS, Brazil

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Erdtmann, B. Aspects of evaluation, significance, and evolution of human C-band heteromorphism. Hum Genet 61, 281–294 (1982). https://doi.org/10.1007/BF00276592

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Keywords

  • Internal Medicine
  • Metabolic Disease
  • Present State
  • Length Measurement
  • Staining Method