Skip to main content

Paracentric inversion inv(11) (q21q23) in the Netherlands

Human Genetics volume 85, pages 15–20 (1990)Cite this article

Summary

We report the result of investigations from 20 families with 72 carriers of the paracentric inversion inv(11)(q21q23) in the Netherlands. There is no increase in the rate of spontaneous abortions among carriers of the inversion or their partners. Also, so far, there are no children with recombinant chromosomes arising from the inversion. It is doubtful whether prenatal diagnosis would be helpful to carriers of this inversion. The results of the genealogy study and geographical distribution are discussed; it is suggested that all the families have arisen from a single mutation.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  • Daniel A, Hook EB, Wulf G (1989) Risks of unbalanced progeny at amniocentesis to carriers of chromosome rearrangements: data from United States and Canadian laboratories. Am J Med Genet 31:14–53

    Google Scholar 

  • Fryns JP, Kleczkowska A, Van den Berghe H (1986) Paracentric inversions in man. Hum Genet 73:205–213

    Google Scholar 

  • Grass FS, Parke JR, Hisley JC (1987) Antenatal diagnosis of a de novo paracentric inversion of chromosome 11. Prenat Diagn 7:1–5

    Google Scholar 

  • Groupe de Cytogénéticiens Français (1986) Paracentric inversions in man. Ann Génét (Paris) 29:169–176

    Google Scholar 

  • Harper PS (1988) Practical genetic counselling, 3rd edn. Wright, London Boston Singapore

    Google Scholar 

  • Madan K (1988) Paracentric inversions and their clinical implications. In: Daniel A (ed) The cytogenetics of mammalian autosomal rearrangements. Liss, New York, pp 249–266

    Google Scholar 

  • Madan K, Seabright M, Lindenbaum RH, Bobrow M (1984) Paracentric inversions in man. J Med Genet 21:407–412

    Google Scholar 

  • Miller K, Raabe G, Schulze B, Schlesinger C (1989) Three rare familial inversions in man (abstract). 10th International Chromosome Conference, Uppsala 1989

  • Nakamura Y, Leppert M, O'Connell P, Wolff R, Holm T, Culver M, Martin C, Fujimoto E, Hoff M, Kumlin E, White R (1987) Variable number of tandem repeat (VNTR) markers for human gene mapping. Science 235:616–622

    Google Scholar 

  • Nakamura Y, Bragg T, Ballard L, Leppert M, O'Connell P, Lathrop GM, Lalouel JM, White R (1988) Isolation and mapping of a polymorphic DNA sequence pYNH37.3 on chromosome 17p (D17S28). Nucleic Acids Res 16:782

    Google Scholar 

  • Raimondi SC, Luthardt FW, Summitt RL, Martens PR (1983) High-resolution chromosome analysis of phenotypically abnormal patients with apparently balanced structural rearrangements. Hum Genet 63:310–314

    Google Scholar 

  • Richkind KE, Neu RL, Puck SM, Elder FFB, Aleck KA (1989) Frequency of inversions in human populations detected at time of prenatal diagnosis (abstract). 10th International Chromosome Conference, Uppsala 1989

  • Stratton RF, Dobyns WB, Airhart SD, Ledbetter DH (1984) New chromosomal syndrome: Miller-Dieker syndrome and monosomy 17p13. Hum Genet 67:193–200

    Google Scholar 

  • Warburton D (1984) Outcome of cases of de novo structural rearrangements diagnosed at amniocentesis. Prenat Diagn 4:69–70

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Human Genetics, Free University, Postbus 7057, NL-1007, MB Amsterdam, The Netherlands

    K. Madan & L. P. Kuyt

  2. Department of Genetics and Cell Biology, University of Limburg, Postbus 616, NL-6200, MD Maastricht, The Netherlands

    M. H. E. C. Pieters & A. J. H. Hamers

  3. Institute of Human Genetics, University of Amsterdam, Meibergdreef 15, NL-1105, AZ Amsterdam, The Netherlands

    C. J. van Asperen

  4. Clinical Genetics Centre, Postbus 18009, NL-3501, CA Utrecht, The Netherlands

    J. M. de Pater

  5. Regional Pathological Laboratory, Edo Bergsmalaan 1, NL-7512, AD Enschede, The Netherlands

    K. B. J. Gerssen-Schoorl

  6. Institute of Human Genetics, Catholic University of Nijmegen, Geert Grooteplein Zuid 10, NL-6500, HB Nijmegen, The Netherlands

    T. W. J. Hustinx & D. F. C. M. Smeets

  7. Institute of Human Genetics, University of Groningen, Antonius Deusinglaan 4, NL-9713, AW Groningen, The Netherlands

    A. S. P. M. Breed

  8. Department of Clinical Genetics, Dijkzigt Academic Hospital, Erasmus University, Postbus 1738, NL-3000, DR Rotterdam, The Netherlands

    J. O. Van Hemel

Authors
  1. K. Madan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. H. E. C. Pieters
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. P. Kuyt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. J. van Asperen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. M. de Pater
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. J. H. Hamers
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. K. B. J. Gerssen-Schoorl
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. T. W. J. Hustinx
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. S. P. M. Breed
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. J. O. Van Hemel
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. D. F. C. M. Smeets
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Madan, K., Pieters, M.H.E.C., Kuyt, L.P. et al. Paracentric inversion inv(11) (q21q23) in the Netherlands. Hum Genet 85, 15–20 (1990). https://doi.org/10.1007/BF00276319

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00276319

Keywords

  • Internal Medicine
  • Metabolic Disease
  • Geographical Distribution
  • Prenatal Diagnosis
  • Spontaneous Abortion