Summary
Maroon-like homozygotes are completely deficient for xanthine dehydrogenase (XDH) and aldehyde oxidase (AO), however ma-l is not a structural locus for either enzyme. Quantitative immunoelectrophoresis of ma-l and wild type extracts suggests that the ma-l function must be post-translational. To determine whether the ma-l function involves some direct physical changes in XDH and/or AO the enyzmes were characterized with respect to temperature sensitivity and behavior in gel sieving electrophoresis. Since the XDH and AO from complementary ma-l heterozygotes is more thermolabile and different in shape from wild type XDH and AO, we conclude that ma-l is involved in a post-translational modification of these enzymes.
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Communicated by M.M. Green
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Finnerty, V., McCarron, M. & Johnson, G.B. Gene expression in Drosophila: Post-translational modification of aldehyde oxidase and xanthine dehydrogenase. Molec. Gen. Genet. 172, 37–43 (1979). https://doi.org/10.1007/BF00276213
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DOI: https://doi.org/10.1007/BF00276213