Summary
The relation of the nucleotide sequences in the coding regions of natural templates and of the short nucleotide sequence in 3′ terminus of 16 S ribosomal RNA was found to differ from random pattern. The observation is interpreted in terms of both the ribosomal interactions and the molecular evolution.
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Berger, E.M.: Pattern and chance in the use of the genetic code. Jour. Molec. Evol. 10, 319–323 (1978)
Bosch, L., Baan, R.A., van Boom, J.H., Caskey, C.T., van Dieijen, G., van Duin, J., Hilbers, C.W., van der Hofstadt, G.A.J.M., van Knippenberg, P.H., van der Laken, C.J., Naaktgeboren, N.: Structure and function of the 3′-terminus of 16S rRNA in relation to polypeptide initiation, elongation and termination. In: Translation of natural and synthetic polynucleotides (ed. Legocki, A.B.), Poznań (Poland) Publishers of Poznań Agricultural University 1977
Chen, C.S., Nakamoto, T.: Translational specifity of Bacillus stearothermophilus ribosomes. Proc. Natl. Acad. Sci. 75, 161–171 (1978)
Elton, R.A., Fiers, W.: Rhythmic variations in purine run frequencies in bacteriophage RNA. Jour. Theor. Biol. 63, 49–59 (1976)
Ehresmann, Ch., Stiegler, P., Mackie, G.A., Zimmermann, R.A., Ebel, J.P., Fellner, P.: Primary sequence of the 16 S ribosomal RNA of Escherichia coli. Nucl. Acids Res. 2, 265–278 (1975)
Fiers, W., Contreras, R., Duerinck, F., Haegeman, G., Iserentant, D., Merregaert, J., Min Jou, W., Molemans, F., Raeymaekers, A., van den Berghe, A., Volckaert, G., Ysebaert, M.: Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene. Nature 260, 500–507 (1976)
Gottesman, M.E.: Reaction of ribosome-bound peptidyl-tRNA with aminoacyl-tRNA or puromycin. Jour. Biol. Chem. 242, 5564–5571 (1967)
Heijne, G. von, Nilsson, L., Blomberg, C.: Translation and messenger RNA secondary structure. Jour. Theor. Biol. 68, 321–329 (1977)
Sander, G.: Mechanism of action of colicin E 3. Effect on ribosomal elongation-factor-dependent reactions. Eur. J. Biochem. 75, 523–531 (1977)
Sanger, F., Air, G.M., Barrel, B.G., Brown, N.L., Coulson, A.R., Fiddes, J.C., Hutchinson III C.A., Slocombe, P.M., Smith, M.: Nucleotide sequence of bacteriophage πX 174 DNA. Nature 265, 687–695 (1977)
Sedláček, J., Rábry, M., Fychlík, I., Volný, D., Vítek, A.: Base pairing mRNA-rRNA. I. The arrangement of nucleotides in the message for coat protein of phage MS 2. Acta Virologica 22, 353–361 (1978)
Shine, J., Dalgarno, L.: The 3′-terminal sequence of E. coli 16 S ribosomal RNA: Complementarity to nonsense triplets and ribosome binding sites. Proc. Natl. Acad. Sci. 71, 1342–1346 (1974)
Sugimoto, K., Sugisaki, H., Okamoto, T., Takanami, M.: Studies on bacteriophage fd DNA. IV. The sequence of messenger RNA for the major coat protein gene. Jour. Molec. Biol. 111, 487–507 (1977)
Springer, M., Grunberg-Manago, M.: Characteristics of N-Ac-Phe-tRNA binding and its correlation with internal aminoacyl-tRNA recognition. Biochem. Biophys. Res. Comm. 47, 477–484 (1972)
Weissmann, C.: The making of a phage. FEBS Letters Supl. 40, 10–18 (1974)
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Communicated by H.G. Wittmann
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Sedláček, J., Fábry, M., Rychlik, I. et al. The arrangement of nucleotides in the coding regions of natural templates. Molec. Gen. Genet. 172, 31–36 (1979). https://doi.org/10.1007/BF00276212
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DOI: https://doi.org/10.1007/BF00276212