Abstract
In this paper we address the following question: can a single cell of the cellular slime mold Dictyostelium discoideum serve as a pacemaker for the aggregation phase? Whether or not this is possible is determined by the relative importance of cyclic AMP production due to self-stimulation as compared to diffusion of cyclic AMP away from the cell and extracellular degradation. We determine the conditions under which a single cell on an infinite place can emit periodic signals of cyclic AMP using a model developed previously for signal relay and adaptation in Dictyostelium. Elsewhere it has been shown that this model provides an accurate representation of the stimulus-response behavior of Dictyostelium for a variety of experimental conditions.
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Research supported in part by NIH Grant # GM 29123
Research supported in part by grants from AFOSR and NSF
Research supported in part by NIH Grant # GM 29123
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DeYoung, G., Monk, P.B. & Othmer, H.G. Pacemakers in aggregation fields of Dictyostelium discoideum: does a single cell suffice?. J. Math. Biology 26, 487–517 (1988). https://doi.org/10.1007/BF00276057
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DOI: https://doi.org/10.1007/BF00276057