Summary
The M variant of encephalomyocarditis virus (EMC) produces a disease similar to human insulin-dependent diabetes mellitus in some but not all strains of mice. This diabetogenic M variant was found to induce fivefold more interferon than non-diabetogenic strains of EMC in cultures of mouse L 929 fibroblasts. When interferon induced by the M variant was added to monolayers of B cells from both diabetes-‘susceptible’ CD-1 mice and ‘resistant’ C57 bl/6 mice before EMC infection, B cell damage and virus replication were delayed. In addition, viral production in B cell cultures from C57 bl/6 mice was reduced five-to tenfold. A similar effect was not found when cultures from CD-1 mice were treated with interferon. Thus, interferon might play an important role in modulating the severity of the initial infection of B cells.
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Wilson, G.L., Bellomo, S.C. & Craighead, J.E. Effect of interferon on encephalomyocarditis virus infection of cultured mouse pancreatic B cells. Diabetologia 24, 38–41 (1983). https://doi.org/10.1007/BF00275945
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DOI: https://doi.org/10.1007/BF00275945