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Mutations in rDNA

3. Modulatory action of α-amanitin on aberration induction in nucleolus organizer regions

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Summary

The action of α-amanitin, an inhibitor of RNA synthesis, on the induction by hydroxyurea (HU) of chromosomal aberrations in nucleolus organizer regions of barley was studied. The data obtained show that α-amanitin can effectively modify aberration induction in rDNA. Administered before mutagen treatment or in combination with the mutagen, the toxin significantly decreased the HU-induced aberration frequencies in NORs. The data obtained provide further evidence that α-amanitin is an effective modulator of aberration induction in NORs either by interfering with RNA synthesis or by modifying chromatin structure.

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Authors and Affiliations

  1. Zentralinstitut für Genetik und Kulturpflanzenforschung, DDR-4325, Gatersleben, German Democratic Republic

    H. Nicoloff & R. Rieger

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  1. H. Nicoloff
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  2. R. Rieger
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Communicated by H. F. Linskens

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Nicoloff, H., Rieger, R. Mutations in rDNA. Theoret. Appl. Genetics 70, 178–184 (1985). https://doi.org/10.1007/BF00275319

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  • DOI: https://doi.org/10.1007/BF00275319

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