Summary
Dimercaprol, calcium disodium edetate, 1-10-phenantroline and 2,2′-dipyridyl were injected intraperitoneally in adult albino rats in doses ranging from 10 to 1500 mg per kg body weight. Ten animals were injected intracerebrally. At various survival times (2 minutes to several hours) their effects on the staining pattern of heavy metals as revealed by the sulfide silver method of Timm were determined. EDTA was virtually ineffective while dimercaprol, phenantroline and dipyridyl reduced the staining in many regions of the brain. A noteworthy effect of phenantroline was that it reduced the staining of a cortical area, corresponding remarkably well in extent, shape and location to the neocortical somatosensory area.
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Fredens, K., Danscher, G. The effect of intravital chelation with dimercaprol, calcium disodium edetate, 1-10-phenantroline and 2,2′-dipyridyl on the sulfide silver stainability of the rat brain. Histochemie 37, 321–331 (1973). https://doi.org/10.1007/BF00274968
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DOI: https://doi.org/10.1007/BF00274968