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Systems analysis of biological receptors

II. The transfer characteristics of the frog muscle spindle

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Zusammenfassung

Zur Erfassung der Übertragungseigenschaften der Froschmuskelspindel wurden die wichtigsten Systemparameter — Länge und Kraft der intrafusalen Muskelfasern, das Verhalten des Receptorpotentials, und die Impulsdichte — bestimmt. Hierbei wurden rampen- und sinusförmige Längen- bzw. Kraftänderungen auf den Muskel aufgebracht und die Veränderungen im Receptorpotential und der Impulsantwort analysiert. Die experimentellen Befunde lassen den Schluß zu, daß der mechano-elektrische Transduktionsprozeß einen wesentlichen Beitrag zur Dynamik liefert, wobei Längenänderungen des Muskels den unmittelbaren Eingang für den Spindel-Transducer darstellen. Abhängig davon, ob die intrafusalen Muskelfasern gedehnt werden oder sich verkürzen können, zeigen die Receptorpotentialänderungen ein PDT1- bzw. ein Verzögerungs-Verhalten. Mögliche molekulare Mechanismen des lonentransportes durch die Receptormembran werden zur Erklärung dieser Änderungen in den Transducereigenschaften herangezogen. Die Formulierung eines linearen Modells gestattet eine hinreichend genaue Beschreibung der einzelnen Teilsysteme: Muskel, Transducer und Encoder sowie der komplexen Receptordynamik. Nur im Bereich großer Längenänderungen, wo der sog. overstretch auftritt, reicht die lineare Approximation nicht mehr aus.

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Authors and Affiliations

  1. Department of Biocybernetics Magdeburg, Advanced College of Technology, DDR

    R. Coenen &  R. A. Chaplain

  2. Physiologisches Institut der Joh. Gutenberg-Universität, Mainz Obere Zahlbacher Straße 67, D-6500, Bundesrepublik Deutschland

    R. A. Chaplain

Authors
  1. R. Coenen
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  2. R. A. Chaplain
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Coenen, R., Chaplain, R.A. Systems analysis of biological receptors. Kybernetik 13, 183–193 (1973). https://doi.org/10.1007/BF00274884

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