Abstract
A detailed histological study was carried out on the major intracranial arteries of 20 mature newborn. A substantial reduction of the reticular fiber content within the wall of the cerebral arteries was observed in all samples originating from infants with intracranial hemorrhage. No other differences occurred when comparisons were made using the conventional staining methods on the vessels from the ten newborn with hemorrhage and the ten others without bleeding. These data indicate that the structural deficiency of the brain vasculature provides the morphological basis for the development of intracranial hemorrhages in the term newborn.
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References
Anderson FM (1952) Subdural hematoma, a complication of operation for hydrocephalus. Pediatrics 10:11–17
Cartwright GW, Culbertson K, Schreiner RL, Garg BP (1979) Changes in clinical presentation of term infants with intracranial hemorrhage. Dev Med Child Neurol 31:730–737
Chaplin ER, Goldstein GW, Norman D (1979) Neonatal seizures, intracerebral hematoma, and subarachnoid hemorrhage in full-term infants. Pediatrics 63:812–815
Craig WS (1938) Intracranial hemorrhage in the newborn: a study of diagnosis and differential diagnosis based upon pathological and clinical findings in 126 cases. Arch Dis Child 13:89–123
Donat JF, Okazaki H, Kleinberg F, Reagan TJ (1978) Intraventricular hemorrhages in full-term and premature infants. Mayo Clin Proc 53:437–441
Fenichel GM, Webster DL, Wong WKT (1984) Intracranial hemorrhage in the term newborn. Arch Neurol 41:30–34
Friede RL (1975) Developmental neuropathology. Springer, New York Heidelberg Berlin
Goldstein GW, Donn SM (1984) Periventricular and intraventricular hemorrhages. In: Sarnat HB (ed) Topics in neonatal neurology. Grune & Stratton, New York, pp 83–108
Guekos-Thöni M, Boltshauser E, Willi UV (1982) Intraventricular haemorrhage in full-term neonates. Dev Med Child Neurol 24:704–705
Hegedüs K (1984) Some observations on reticular fibers in the media of the major cerebral arteries. A comparative study of patients without vascular diseases and those with ruptured berry aneurysms. Surg Neurol 22:301–307
Hegedüs K, Molnár P (1985) Histopathological study of major intracranial arteries in premature infants related to intracranial hemorrhage. J Neurosurg 62:419–424
Hill A, Volpe JJ (1981) Seizures, hypoxic-ischemic brain injury, and intraventricular hemorrhage in the newborn. Ann Neurol 10:109–121
Lacey DJ, Terplan K (1980) Intraventricular hemorrhage in full-term neonate. Ann Neurol 8:227 (abstr)
Larroche JC (1977) Developmental pathology of the neonate. Excerpta Medica, New York Amsterdam
Leblanc R, O'Gorman AM (1980) Neonatal intracranial hemorrhage: a clinical and serial computerized tomographic study. J Neurosurg 53:642–651
Menezenes AH, Smith DE, Bell WE (1983) Posterior fossa hemorrhage in the term neonate. Neurosurgery 13:452–456
Mitchell W, O'Tuama L (1980) Cerebral intraventricular hemorrhages in infants: a widening age spectrum. Pediatrics 65:35–39
Nanba E, Eda I, Takashima S, Ohta S, Oktani K, Takeshita K (1984) Intracranial hemorrhage in the full-term neonate and young infant: correlation of the location and outcome. Brain Dev 6:435–443
Palma PA, Miner ME, Morriss FH, Adcock III EV, Denson SE (1979) Intraventricular hemorrhage in the neonate born at term. Am J Dis Child 133:941–944
Pape KE, Wigglesworth JS (1979) Haemorrhage, ischemia and the perinatal brain. Lippincott, Philadelphia
Povlishock JT, Martinez AJ, Moossy J (1977) The fine structure of blood vessels of the telencephalic germinal matrix in the human fetus. Am J Anat 149:439–452
Ross JJ, Dimmette RM (1965) Subependymal cerebral hemorrhage in infancy. Am J Dis Child 110:531–542
Saunders C (1943) Intracranial hemorrhage in the newborn. J Obstet Gynaecol Br Emp 55:55–61
Scher MS, Wright FS, Lockman LA, Thompson TR (1982) Intraventricular hemorrhage in the full-term neonate. Arch Neurol 39:769–772
Serfontein GL, Rom S, Stein S (1980) Posterior fossa subdural hemorrhage in the newborn. Pediatrics 65:40–43
Volpe JJ (1981) Neurology of the newborn. Saunders, Philadelphia
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Hegedüs, K., Molnár, P. On the pattern of reticular fibers in the intracranial arteries of mature newborn with and without intracranial hemorrhage. Child's Nerv Syst 2, 2–4 (1986). https://doi.org/10.1007/BF00274024
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DOI: https://doi.org/10.1007/BF00274024