Summary
The two genetic complementation groups reported for Fanconi's anemia (FA) correspond to two phenotypic classes as characterized by measurements of the rate of DNA semiconservative synthesis after 8-methoxypsoralen photo-addition. This test allows a rapid genetic classification of FA patients which appears to be a prerequisite for investigations of the biochemical defect(s) in FA.
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Moustacchi, E., Papadopoulo, D., Diatloff-Zito, C. et al. Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment. Hum Genet 75, 45–47 (1987). https://doi.org/10.1007/BF00273837
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DOI: https://doi.org/10.1007/BF00273837