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The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter

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Summary

Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21→6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.

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Authors and Affiliations

  1. Department of Hormone Research, The Weizmann Institute of Science, 76100, Rehovot, Israel

    Illana Gozes & Rina Avidor

  2. Department of Pediatrics A, Sheba Medical Center, Tel Hashomer, Israel

    Yaakov Yahav & Daniel Katznelson

  3. The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Carlo M. Croce & Kay Huebner

Authors
  1. Illana Gozes
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  2. Rina Avidor
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  3. Yaakov Yahav
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  4. Daniel Katznelson
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  5. Carlo M. Croce
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  6. Kay Huebner
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Gozes, I., Avidor, R., Yahav, Y. et al. The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter. Hum Genet 75, 41–44 (1987). https://doi.org/10.1007/BF00273836

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  • DOI: https://doi.org/10.1007/BF00273836

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