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Single cell translocations in couples with multiple spontaneous abortions

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Summary

Single cell translocations have been previously reported to occur in normal lymphocyte cultures. Comparison of the frequency of these in 140 individuals referred for a history of multiple miscarriages and 415 individuals referred for other reasons showed a significantly greater number of single cell translocations in the former group. This group also had a significantly greater number of other types of single cell structural abnormalities. Increased chromosome instability, chromosome mosaicism, residual fetal trophoblasts, and immunological differences are discussed in considering the possible etiology.

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Authors and Affiliations

  1. Department of Medical Genetics, James Whitcomb Riley Hospital for Children RR129, Indiana University Medical Center, 702 Barnhill Drive, 46223, Indianapolis, IN, USA

    Michael D. Higgins & Catherine G. Palmer

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  1. Michael D. Higgins
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  2. Catherine G. Palmer
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Higgins, M.D., Palmer, C.G. Single cell translocations in couples with multiple spontaneous abortions. Hum Genet 75, 24–27 (1987). https://doi.org/10.1007/BF00273833

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  • DOI: https://doi.org/10.1007/BF00273833

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