Summary
A fragile site on chromosome 12, at 12q24.13, was found in the lymphocytes of two members of a family during the study for detection of a fragile X chromosome. The site was found to be heritable and folate-sensitive, and it fulfills all four criteria for a fragile site. It thus can now be confirmed as the heritable fragile site FRA12C.
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References
De Brackeleer M, Smith B, Lin CC (1985) Fragile sites and structural rearrangements in cancer. Hum Genet 69:112–116
Human Gene Mapping (1985) Helsinki Conference, Eighth International Workshop on Human Gene Mapping. Cytogenet Cell Genet 40:490–494
Ikeuchi T (1984) Inhibitory effect of ethidium bromide on mitotic chromosome condensation and its application to high-resolution banding. Cytogenet Cell Genet 38:56–61
Le Beau MM, Rowley JD (1984) Heritable fragile sites in cancer. Nature 308:607–608
Le Beau MM (1986) Chromosomal fragile sites and cancer-specific rearrangements. Blood 67:849–858
Shabtai F, Klar D, Halbrecht I (1982) Chromosome 17 has a real fragile site at p12. Hum Genet 61:177–179
Shabtai F, Klar D, Nissimov R, Vardimon D, Hart J, Halbrecht I (1983) A new familial “fragile site” on chromosome 16 (q23–24). Cytogenetic and clinical considerations. Hum Genet 64:273–276
Sherman SL, Sutherland GR (1986) Segregation analysis of rare autosomal fragile sites. Hum Genet 72:123–128
Sutherland GR (1979a) Heritable fragile sites on human chromosomes. I. Factors affecting expression in lymphocyte culture. Am J Hum Genet 31:125–135
Sutherland GR (1979b) Heritable fragile sites on human chromosomes. II. Distribution, phenotypic effects, and cytogenetics. Am J Hum Genet 31:136–148
Sutherland GR, Hecht F (1985) Fragile sites on human chromosomes. Oxford University Press, New York
Sutherland GR, Parslow MI, Baker E (1985) New classes of common fragile sites induced by 5-azacytidine and bromodeoxyuridine. Hum Genet 69:233–237
Webb T, Thake A (1984) Fragile 22q13 segregating in a family. Clin Genet 26:125–128
Yunis JJ (1984) Fragile sites and predisposition to leukemia and lymphoma. Cancer Genet Cytogenet 12:85–88
Yunis JJ, Soreng AL (1984) Constitutive fragile sites and cancer. Science 7:1199–1204
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Amarose, A.P., Huttenlocher, P.R., Sprudzs, R.M. et al. A heritable fragile 12q24.13 segregating in a family with the fragile X chromosome. Hum Genet 75, 4–6 (1987). https://doi.org/10.1007/BF00273829
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DOI: https://doi.org/10.1007/BF00273829