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Glucose-6-phosphate dehydrogenase variants and their frequency in Guangdong, China

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Summary

Erythrocyte glucose-6-phosphate dehydrogenase (G6PD) was characterized in blood samples obtained from 97 randomly selected males with enzyme deficiency from various regions of Guangdong Province, China. Nine new variants (Gd Kaiping, Gd Boluo, Gd Huiyang, Gd Gaomin, Gd Qing-Baijiang, Gd Gaozhou, Gd Huazhou, Gd Nanhai, and Gd Guangzhou) were identified. Of the 31 variants found in this province, Gd Kaiping, Gd Taiwan-Hakka, Gd Haad Yai, Gd Haad Yai-like and Gd Huiyang occurred most frequently. The frequency of each variant was calculated. The results demonstrated that the genetic heterogeneity of G6PD deficiency was high in this area.

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References

  • Chan TK, Todd D (1972) Characterization and distribution of glucose-6-phosphate dehydrogenase-deficient variants in South China. Am J Hum Genet 24:475–484

    Google Scholar 

  • Chockkalingam K, Board PG, Nurse GT (1982) Glucose-6-phosphate dehydrogenase, deficiency in Papua, New Guinea. The description of 13 new variants. Hum Genet 60:189–192

    Google Scholar 

  • Du CS, Rui L (1981a) A qualitative nitrotetrazolium blue paper strip method for screening of G6PD deficiency. N Chin Med 12:186–187

    Google Scholar 

  • Du CS, Rui L (1981b) Nitrotetrazolium blue method for the quantitative determination of erythrocyte glucose-6-phosphate dehydrogenase activity. Chin J Hematol 2:188–192

    Google Scholar 

  • Du CS, Xu YK, Wu QL, Liu LB, Wu M (1984) Studies on erythrocyte glucose-6-phosphate dehydrogenase variants in Chinese. III. Gd(-) Miaozu-Baisha. Acta Genet Sinica 11:153–158

    Google Scholar 

  • Du CS, Hua XY, Wu QL, Li CQ, Zhen JF, L HL (1985a) Studies on erythrocyte glucose-6-phosphate dehydrogenase variants in Chinese. IV. Gd(-) Gaohe associated with paroxysmal nocturnal hemoglobinuria. Chin J Pathophysiol 1:12–15

    Google Scholar 

  • Du CS, Hua XY, Liu LB, Wu QL, Xu YK (1985b) Studies on erythrocyte glucose-6-phosphate dehydrogenase variants in Chinese. V. Gd(-) Qingyuan. Heredity Dis 2:205–208

    Google Scholar 

  • Karadsheh NS, Awidi AS, Tarawneh MS (1986) Two new glucose-6-phosphate dehydrogenase (G6PD) variants associated with hemolytic anemia: G6PD Amman-1 and G6PD Amman-2. Am J Hematol 22:185–192

    Google Scholar 

  • McCurdy PR, Kirkman HN, Naiman JL, Jim RTS, Pickard BM (1966) A Chinese variant of glucose-6-phosphate dehydrogenase. J Lab Clin Med 67:374–385

    Google Scholar 

  • Nakashima K, Ono J, Abe S, Miwa S, Yoshida A (1977) A glucose-6-phosphate dehydrogenase variant found in four unrelated Japanese families. Am J Hum Genet 29:24–30

    Google Scholar 

  • Panich V, Na-Nakorn S (1980) G6PD variants in Thailand. J Med Assoc Thai 63:537–542

    Google Scholar 

  • Panich V, Bumrungtrakul P, Jitjai C, Kamolmatayakul S, Khoprasert B, Klaisuvan C, Kongmuang U, Maneechai P, Pornpatkul M, Ruengrairatanaroje P, Surapruk P, Viriya-yudhakorn S (1980) Glucose-6-phosphate dehydrogenase deficiency in South Vietnamese. Hum Hered 30:361

    Google Scholar 

  • Parsons IC, Ryan BPK (1962) Observations on glucose-6-phosphate dehydrogenase deficiency in Papuans. Med J Aust 2:585–587

    Google Scholar 

  • Toncheva D (1986) Variants of glucose-6-phosphate dehydrogenase in a Vietnamese population. Hum Hered 36:348–351

    Google Scholar 

  • WHO Scientific Group (1967) Standardization of procedures for the study of glucose-6-phosphate dehydrogenase. WHO Tech Rep Ser 366:1–53

    Google Scholar 

  • Xu YK, Zheng RP, Liu LB, Hua XY, Zhong JP, Zhu XP, Wu M, Du CS (1985) Investigation of red cell glucose-6-phosphate dehydrogenase deficiency gene frequency in 9 nationality populations in 7 provinces (Autonomous Regions). Heredity Dis 2:67–71

    Google Scholar 

  • Yoshida A, Beutler E (1978) Human glucose-6-phosphate dehydrogenase variants: a supplementary tabulation. Ann Hum Genet 41: 347–355

    Google Scholar 

  • Yoshida A, Beutler E (1983) G6PD variants: another up-date. Ann Hum Genet 47:25–38

    Google Scholar 

  • Zinkham WH, Lenhard RE, Child BA (1958) A deficiency of glucose-6-phosphate dehydrogenase activity in erythrocytes from patients with favism. Bull Johns Hopkins Hosp 102:169–175

    Google Scholar 

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Authors and Affiliations

  1. Department of Medical Genetics, Sun Yat Sen University of Medical Sciences, Zhongshan Road II, Guangzhou, The People's Republic of China

    C. S. Du, Y. K. Xu, X. Y. Hua, Q. L. Wu & L. B. Liu

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  1. C. S. Du
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  2. Y. K. Xu
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  3. X. Y. Hua
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  4. Q. L. Wu
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  5. L. B. Liu
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Du, C.S., Xu, Y.K., Hua, X.Y. et al. Glucose-6-phosphate dehydrogenase variants and their frequency in Guangdong, China. Hum Genet 80, 385–388 (1988). https://doi.org/10.1007/BF00273657

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  • DOI: https://doi.org/10.1007/BF00273657

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