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Phase II study of a new alkylating agent (PTT-119) in resistant-relapsed non-Hodgkin's lymphomas

Cancer Chemotherapy and Pharmacology volume 23, pages 123–125 (1989)Cite this article

Summary

In a phase II study we evaluated the effect and toxicity of a new alkylating agent, PTT-119, in 26 patients with non-Hodgkin's lymphomas (NHL) resistant to or relapsed alter other chemotherapy. PTT was scheduled by ascalating the dose from 2.0 to 3.3 mg/kg every 3 weeks. Among 21 evaluable patients with NHL, 12 (57%) showed a good response (CR+PR) to PTT-119. Tolerance was acceptably good; no major side effects related to liver, cardiac, or renal toxicity were recorded. The most commonly recorded side effects were nausea and vomiting, alopecia, and phlebitis; diarrhea and drug-related fever were rarely seen. This report indicates a potential usefulness for PTT-119, a non-cross-resistant alkylating agent, in the treatment of NHL.

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Affiliations

  1. Institute of Hematology “L. e A. Seragnoli”, University of Bologna, Italy

    S. Tura, P. Mazza, F. Gherlinzoni, P. L. Zinzani, G. Poletti, G. Visani, R. M. Lemoli, M. Cavo, P. Galieni, C. Tassi & R. Zanchini

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  1. S. Tura
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  2. P. Mazza
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  3. F. Gherlinzoni
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  4. P. L. Zinzani
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  5. G. Poletti
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  6. G. Visani
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  7. R. M. Lemoli
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  8. M. Cavo
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  9. P. Galieni
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  10. C. Tassi
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  11. R. Zanchini
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This work was supported by Fondi Ministero Publica Istruzione

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Tura, S., Mazza, P., Gherlinzoni, F. et al. Phase II study of a new alkylating agent (PTT-119) in resistant-relapsed non-Hodgkin's lymphomas. Cancer Chemother. Pharmacol. 23, 123–125 (1989). https://doi.org/10.1007/BF00273532

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  • DOI: https://doi.org/10.1007/BF00273532

Keywords

  • Lymphoma
  • Cancer Research
  • Diarrhea
  • Alopecia
  • Evaluable Patient