Summary
The specific, receptor-dependent 5α-dihydrotestosterone-binding capacity of cultured fibroblasts derived from genital and nongenital skin has been compared. With the methods employed, the detectable amount of the DHT receptor in nongenital skin-derived fibroblasts is variable, often approaching the limit of detectability. Therefore it is concluded that for differential diagnosis of disorders of sexual development, DHT-binding studies should be performed with genital skin fibroblasts only.
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Herfert, J., Wienker, T.F. & Ropers, H.H. The presence of androgen-binding receptors in genital and nongenital skin fibroblasts. Hum Genet 53, 271–273 (1980). https://doi.org/10.1007/BF00273510
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DOI: https://doi.org/10.1007/BF00273510