Summary
A total of 701 individuals from a village in The Gambia, West Africa were tested for serum α1 - antitrypsin phenotypes by isoelectric focusing in thinlayer polyacrylamide gels (pH 4-5). A new variant allele, Pi GAM, was discovered at a polymorphic frequency (0.0642), and the inheritance of the variant phenotype was confirmed by family studies. The variant was not found to be associated with any decrease in serum α1 - concentration. The only other allele found within this population was the common allele Pi M(0.9358).
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Welch, S.G., McGregor, I.A. & Williams, K. α1-antitrypsin (Pi) phenotypes in a village population from the Gambia, West Africa. Hum Genet 53, 233–235 (1980). https://doi.org/10.1007/BF00273503
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DOI: https://doi.org/10.1007/BF00273503