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Temporary increase in chromosome breakage in an infant prenatally exposed to lead

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Summary

An infant exposed to high levels of lead in utero was found to have increased numbers of cells with chromosome breaks in blood samples obtained at 6 weeks and 3 months of life. Later samples did not show significant abnormality. Physical and neurological examinations of the patient up to 18 months of age gave results within normal limits.

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References

  • Angle, C. R., McIntire, M. S.: Lead poisoning during pregnancy. Am. J. Dis. Child. 108, 436–439 (1964)

    Google Scholar 

  • Aula, P., Koskull, H. von: Distribution of spontaneous chromosome breaks in human chromosomes. Hum. Genet. 32, 143–148 (1976)

    Google Scholar 

  • Biondi, C.: Occupation and health. Geneva: International Labour Office, 1934

    Google Scholar 

  • Carpenter, S. J.: Placental permeability of lead. Env. Health Perspect. 7, 129–131 (1974)

    Google Scholar 

  • Ferm, V. H., Carpenter, S. J.: Developmental malformations resulting from the administration of leads salts. Exp. Mol. Pathol. 7, 208–213 (1967)

    Google Scholar 

  • Forni, A., Secchi, G. C.: Chromosome changes in preclinical and clinical lead poisoning and correlation with biochemical findings. Proceeding of the International Symposium on Environmental Health Aspects of Lead. Amsterdam: October 2–6, 1972, pp. 473–485

  • Gershanik, J. J., Brooks, G. G., Little, J. A.: Blood lead values in pregnant women and their offspring. Am. J. Obstet. Gynecol. 119, 508–511 (1974)

    Google Scholar 

  • Kostial, K., Momcilovic, B.: Transport of lead 203 and calcium from mother to offspring. Arch. Environ. Health. 29, 28–30 (1974)

    Google Scholar 

  • Lehnert, G.: Chromosomal aberrations due to the effect of lead. Conference on Chemical Pollution and Human Ecology, Prague, October 2–6, 1970

  • Moorehead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., Hungerford, D. A.: Chromosome preparations of leukocytes cultured from human peripheral blood. Exp. Cell Res. 20, 613–616 (1960)

    Google Scholar 

  • Muro, L. A., Goyer, R. A.: Chromosome damage in experimental lead poisoning. Arch. Pathol. 87, 660–663 (1969)

    Google Scholar 

  • Rom, W. N.: Effects of lead on the female and reproduction: A review. Mt. Sinai J. Med. (N.Y.) 43, 542–552 (1976)

    Google Scholar 

  • Ryu, J. E., Ziegler, E. E., Fomon, S. J.: Maternal lead exposure and blood lead concentration in infancy. J. Pediatr. 93, 476–478 (1978)

    Google Scholar 

  • Schwanitz, G., Lehnert, G., Gebhart, E.: Chromosomal injury due to occupational lead poisoning. Germ. Med. Mth. 15, 738–746 (1970)

    Google Scholar 

  • Schwanitz, G., Gebhart, K., Rott, H. D., Schaller, K. H., Essing, H. G., Lauer, O., Prestele, H.: Chromosomenuntersuchungen bei Personen mit beruflicher Bleiexposition. Dtsch. Med. Wochenschr. 100, 1007–1011 (1975)

    Google Scholar 

  • Singh, N., Donovan, C. M., Hanshaw, J. B.: Neonatal lead intoxication in prenatally exposed infant. J. Pediatr. 93, 1019–1021 (1978)

    Google Scholar 

  • Weller, C. V.: The blastothoric effect of chronic lead poisoning. J. Med. Res. 33, 271–272 (1915)

    Google Scholar 

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Qazi, Q.H., Madahar, C. & Yuceoglu, A.M. Temporary increase in chromosome breakage in an infant prenatally exposed to lead. Hum Genet 53, 201–203 (1980). https://doi.org/10.1007/BF00273496

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  • DOI: https://doi.org/10.1007/BF00273496

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