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The second human calcitonin/CGRP gene is located on chromosome 11

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Summary

A second human calcitonin/calcitonin gene related peptide (hCT/CGRP) gene has been identified. This second hCT/CGRP gene has been shown to contain sequences highly homologous to exons 3, 5 (CGRP-encoding), and 6 of the first hCT/CGRP gene, but sequences closely related to exon 4 (CT-encoding) could not be demonstrated. Southern blot hybridization analysis of DNA from human-rodent somatic cell hybrids showed that the second hCT/CGRP gene is located in the q12-pter region of chromosome 11. The first hCT/CGRP gene has previously been assigned to the p13–p15 region of chromosome 11.

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Authors and Affiliations

  1. Institute of Molecular Biology, University Hospital, State University of Utrecht, The Netherlands

    J. W. M. Höppener & P. H. Steenbergh

  2. Laboratory for Physiological Chemistry, University Hospital, State University of Utrecht, The Netherlands

    J. Zandberg & H. S. Jansz

  3. Department of Internal Medicine, University Hospital, State University of Utrecht, The Netherlands

    C. J. M. Lips

  4. Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands

    A. H. M. Geurts van Kessel

  5. The Oncology Center, The Johns Hopkins Medical Institutions, 21205, Baltimore, MD, USA

    S. B. Baylin & B. D. Nelkin

  6. the Department of Medicine, The Johns Hopkins Medical Institutions, 21205, Baltimore, MD, USA

    S. B. Baylin & B. D. Nelkin

Authors
  1. J. W. M. Höppener
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  2. P. H. Steenbergh
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  3. J. Zandberg
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  4. A. H. M. Geurts van Kessel
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  5. S. B. Baylin
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  6. B. D. Nelkin
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  7. H. S. Jansz
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  8. C. J. M. Lips
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Höppener, J.W.M., Steenbergh, P.H., Zandberg, J. et al. The second human calcitonin/CGRP gene is located on chromosome 11. Hum Genet 70, 259–263 (1985). https://doi.org/10.1007/BF00273453

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  • DOI: https://doi.org/10.1007/BF00273453

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