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Unusual findings by fluorescence microscopy of a t(13q14q)

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Summary

Fluorescence studies in a 13q14q translocation seem to indicate, that the centromeric region of both chromosomes has been preserved. It is assumed, that the 13 centromere, not visible in Giemsa staining, is suppressed by the active 14 centromere. It is emphasized that Robertsonian translocations in man might be due to breaks in the short arms of the involved chromosomes.

Zusammenfassung

Die Färbung einer 13q14q-Translokation mit Quinacrin-Lost scheint zu indicieren, daß die Zentromerregionen beider Chromosomen erhalten sind. Das Zentromer des Chromosoms Nr. 13 ist nicht sichtbar bei Giemsafärbung. Es ist möglich, daß es durch das aktive 14-Zentromer unterdrückt worden ist. Zentrische Fusionen beim Menschen können somit wahrscheinlich durch Brüche an beiden kurzen Armen der implizierten Chromosomen entstehen.

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References

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Authors and Affiliations

  1. John F. Kennedy Institute, Glostrup, Denmark

    E. Niebuhr

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  1. E. Niebuhr
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Niebuhr, E. Unusual findings by fluorescence microscopy of a t(13q14q). Hum Genet 15, 96–98 (1972). https://doi.org/10.1007/BF00273440

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  • DOI: https://doi.org/10.1007/BF00273440

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