Skip to main content
SpringerLink
Log in

An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin

  • Original Articles
  • Autoradiography, Cisplatin, Iproplatin, Carboplatin
  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baer J, Harrison R, McAuliffe CA, Zaki A, Sharma HL, Smith AG (1985) Microscale synthesis of anti-tumour platinum compounds labelled with 191Pt. Int J Appl Radiat Isot 36: 181

    Google Scholar 

  2. Calvert AH, Clagett-Carr K, Leyland-Jones B, Hoth D (1985) Phase I studies with carboplatin at the Royal Marsden Hospital. Cancer Treat Rev 12 [Suppl A]: 51

    Google Scholar 

  3. Chalkley HW (1943) Method for the quantitative morphological analysis of tissues. J Natl Cancer Inst 4: 47

    Google Scholar 

  4. Curt GA, Grygiel JJ, Corden BJ, Ozols RF, Weiss RB, Tell DT, Myers CE, Collins JM (1983) A phase I and pharmacokinetic study of diamminecyclobutane dicarboxylatoplatinum (NSC 241240). Cancer Res 43: 4470

    Google Scholar 

  5. Daley-Yates PT, McBrien DCH (1982) Cisplatin (cis-dichlorodiammine platinum II) nephrotoxicity. In: Bridges JW, Lock EA (eds) Nephrotoxicity assessment and pathogenesis. Wiley, Chichester, p 356

    Google Scholar 

  6. Dobyan DC (1985) Long-term consequences of cis-platinum-induced renal injury: a structural and functional study. Anat Rec 212: 239

    Google Scholar 

  7. Dunn TB (1949) Some observations on the normal and pathologic anatomy of the kidney of the mouse. J Natl Cancer Inst 9: 285

    Google Scholar 

  8. Goren MP, Forastiere AA, Wright RK, Horowitz ME, Dodge RK, Kamen BA, Viar MJ, Pratt CB (1987) Carboplatin (CBDCA), iproplatin (CHIP) and high-dose cisplatin in hypertonic saline evaluated for tubular nephrotoxicity. Cancer Chemother Pharmacol 19: 57

    Google Scholar 

  9. Harrison R, McAuliffe CA, Zaki A, Baer J, Sharma H, Smith A, Jackson H, Fox BW (1983) A comparative study of the distribution in the male rat of platinum-labelled cis-dichlorodiammine platinum (II), cis-trans-dichlorodihydroxy-bis-(iso-propylamine) platinum (IV) and cis-dichloro-bis-cyclopropyl-amine platinum (II). Cancer Chemother Pharmacol 10: 90

    Google Scholar 

  10. Kriz W, Kaissling B (1985) Structural organisation of the mammalian kidney. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven Press, New York, p 265

    Google Scholar 

  11. Jones TW, Chopra S, Kaufman JS, Flamenbaum W, Trump BF (1985) cis-Diamminedichloroplatinum (II)-induced acute renal failure in the rat. Lab Invest 52: 363

    Google Scholar 

  12. Lee FH, Canetta R, Issell BF, Lenaz L (1983) New platinum complexes in clinical trials. Cancer Treat Rev 10: 39

    Google Scholar 

  13. Pendyala L, Madajewicz S, Lele BS, Arbuck SG, Creaven PJ (1985) Evaluation of the nephrotoxicity of iproplatin (CHIP) in comparison to cisplatin by the measurement of urinary enzymes. Cancer Chemother Pharmacol 15: 203

    Google Scholar 

  14. Rose WC, Schurig JE (1985) Preclinical antitumour and toxicologic profile of carboplatin. Cancer Treat Rev 12 [Suppl A]: 1

    Google Scholar 

  15. Safirstein R, Miller P, Cruttenplan JB (1984) Uptake and metabolism of cisplatin by rat kidney. Kidney Int 25: 753

    Google Scholar 

  16. Safirstein R, Winston J, Goldstein M, Moel D, Dikman S, Guttenplan J (1986) Cisplatin nephrotoxicity. Am J Kidney Dis 8: 356

    Google Scholar 

  17. Siddik ZH, Dible SE, Boxall FE (1986) Renal pharmacokinetics and toxicity of cisplatin and carboplatin in animals. In: McBrien DCH, Slater TF (eds) Biochemical mechanisms of platinum anti-tumour drugs. IRL Press, Oxford, p 171

    Google Scholar 

  18. Venkatachalam MA, Bernard DB, Donohoe JF, Levinsky NG (1978) Ischaemic damage and repair in the rat proximal tubule: differences among the S1, S2 and S3 segments. Kidney Int 14: 31

    Google Scholar 

  19. Ward JM, Fauvie KA (1976) The nephrotoxic effects of cis-diammine-dichloroplatinum (II) (NSC-119875) in male F344 rats. Toxicol Appl Pharmacol 38: 535

    Google Scholar 

Download references

Author information

Author notes

  1. C. Ewen

    Present address: C.R.C. Department of Medical Oncology, University of Glasgow, I Horselethill Road, G12 9LX, Glasgow, UK

Authors and Affiliations

  1. Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, M20 9BX, Manchester, UK

    C. Ewen & J. H. Hendry

  2. Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, M20 9BX, Manchester, UK

    B. W. Fox

  3. Department of Chemistry, UMIST, Sackville Street, M60 1QD, Manchester, UK

    A. Perera & C. A. McAuliffe

  4. Department of Medical Biophysics, University of Manchester, Oxford Road, M13 9PT, Manchester, UK

    H. Sharma

Authors
  1. C. Ewen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Perera
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. H. Hendry
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. A. McAuliffe
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. W. Fox
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ewen, C., Perera, A., Hendry, J.H. et al. An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin. Cancer Chemother. Pharmacol. 22, 241–245 (1988). https://doi.org/10.1007/BF00273418

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00273418

Keywords

Search

Navigation