Abstract
Hemoglobin E, an anomaly of the β-chain of human hemoglobin, is widely distributed in Southeast Asia and adjacent areas. In some populations of Southeast Asia the frequency of the gene responsible for the production of HbE reaches values near 0.3. In view of the probable disadvantage of the HbE homozygote and the certain disadvantage of the double heterozygote for the HbE and β-thalassemia genes an advantage of the heterozygote has to be postulated in order to explain the high gene frequencies. There is some evidence for and against malaria protection being the factor conveying heterozygote advantage. Data concerning genotype fitnesses in the triallelic system involving HbA, HbE and β-thalassemia are scanty. Crude fitness data based on clinical observations and equilibrium calculations indicate that the system is unstable. Dynamic models of the three genes suggest that the HbE gene is replacing the β-thalassemia gene in most Southeast Asian populations. The distribution of HbE and that of the austroasiatic group of languages are similar. This and several other aspects of the geographic and ethnic distribution of HbE are discussed in the last section of this review.
Similar content being viewed by others
Literature
Aksoy, M.: Abnormal haemoglobins in Turkey, in: Abnormal Haemoglobins, Instanbul 1957. Oxford: Blackwell 1959.
—: Hemoglobin E in Eti-Turks. Blood 16, 606 (1960).
—: Haemoglobins S and E in Turkish people. Nature (Lond.) 193, 786–787 (1962).
Aksoy, M., G. W. Bird, H. Lehmann, A. E. Mourant. H. Thein, and R. L. Wickremasinghe: Haemoglobin E in Asia. J. Physiol. (Lond.) 130, 56 P. (1955).
—, A. Cetingil, N. Kocabalkan, D. Sestakof, T. Aladag, F. Secer, and N. Bostanci: Thalassaemia-hemoglobin-E-disease in Turkey, with hypersplenism in one case. Amer. J. Med. 34, 851–855 (1963).
— and S. Erdem: The thalassemia syndromes. V. Cooley's anemia with low level of fetal hemoglobin. Acta haemat. (Basel) 34, 291 (1965).
Aksoy, M., E. W. Ikin, A. E. Mourant, and H. Lehmann: Blood groups, haemoglobins and thalassaemia in Turks in South Turkey and Eti-Turks. Brit. med. J. 1958/II, 937–939.
Albahary, C., J. C. Dreyfus, D. Labie, G. Schapira et L. Tram: Hémoglobines anormales au Sud-Vietnam: hémoglobinose C homozygote, trait E, hémoglobine nouvelle. Rev. Hémat. 13, 163 (1958).
Allison, A. C.: The sickle-cell and haemoglobin C gene in some African populations. Ann. hum. Genet. 21, 67 (1956).
—: Genetic factors in resistance to malaria. Ann. N. Y. Acad. Sci. 91, 710 (1961).
—: Polymorphism and natural selection in human populations. Cold Spr. Harb. Symp. quant. Biol. 29, 137–149 (1964).
—, B. A. Askonas, N. A. Barnicot, B. S. Blumberg, and C. Krimbas: Deficiency of erythrocyte glucose-6-phosphate dehydrogenase in Greek populations. Ann. hum. Genet. 26, 237 (1963).
Anderson, J. E.: Anemia and hemoglobin E trait in the Republic of Vietnam. Milit. Med. 131, 148 (1966).
Ayurakit-Kosol, L., and M. E. Griffith: Progress towards malaria eradication in Thailand. In: Proceedings, 9th Pacific Science Congress 17, 122 (1962).
Bannermann, R. M.: Thalassaemia, a survey of some aspects. New York-London: Grune & Stratton 1961.
Banicot, N. A., A. C. Allison, B. S. Blumberg, G. Deliyannis, C. Krimbas, and A. Ballas: Haemoglobin types in Greek populations. Ann. hum. Genet. 26, 229 (1963).
Batu, A. T., and Pe Hla: The haemoglobinpathies in Burma. 1st Burma Med. Res. Conf., Abstract 109 (1965).
Baup, H.: Fréquence de l'hémoglobine E au Laos. Méd. trop. 24, 51 (1964).
Bernini, L., U. Carcassi, B. Latte, A. G. Motulsky, L. Romei e M. Siniscalco: Indagine genetiche sulla predisposizioe al favismo: III. Distribuzione delle frequenze geniche peril locus Gd in Sardegna. Interazione con la malaria e la talassemia al livello populazionistico. Acad. Nat. dei Lincei (Roma) 29, 1 (1960).
Betke, K.: Zum Vorkommen von Haemoglobinanomalien in Deutschland. In: Haemoglobin-Colloquium, Wien 1961. Stuttgart: Thieme 1962.
Blackwell, R., V. Delafuente, R. Florentino, L. Alejo, J. Huang, and L. Chien: Preliminary report on abnormal hemoglobins in Filipinos. J. Philipp. med. Ass. 41, 703 (1965).
—: Abnormal hemoglobin studies in Taiwan aborigines Science 139, 661 (1963).
—, and L. Chien: Distribution of abnormal hemoglobins among normal Chinese residents of Taiwan. Israel J. med. Sci. 1, 759 (1965a).
—, T. H. I. Huang, L. Chien: Abnormal hemoglobin characteristics of Taiwan aborigines. Hum. Biol. 37, 343 (1965b).
—, T. H. I. Huang, and L. Chien Haemoglobin E in Vietnamese. Nature (Lond.) 207, 768 (1965c).
Brain, P.: The distribution of haemoglobin E. Proc. IX Cong. Int. Soc. Haemat., Mexico, Vol. III, 1960.
—, and O. E. Budtz-Olsen: Thalassaemia-haemoglobin E-disease in a Cape-colored family. S. Afr. med. J. 32, 553 (1958).
Brumpt, L. C., and V. Brumpt: Resistance au paludisme et hémoglobines anormales (en particulier hémoglobine E). Bull. Soc. Path. exot. 51, 217–224 (1958).
Brumpt, L. C., V. Brumpt, M. L. Coquelet et P. M. Detraverse: La détection de l'hémoglobine E. Etude des populations cambodgiennes. Rev. Hémat. 13, 21 (1958).
—, P. M. Detraverse et M. L. Coquelet: Intercation entre hémoglobine E et trait thalassémique au Cambodge. C. R. Soc. Biol. (Paris) 150, 147 (1956).
Budtz-Olsen, O. E.: Haptoglobins and haemoglobins in Australian aborigines, with a simple method for the estimation of haptoglobin. Med. J. Aust. 2, 689–693 (1958).
Buettner-Janusch, V., and J. Buettner-Janusch. Hemoglobins, haptoglobins and transferrins in the people of Madagascar. Amer. J. Phys. Anthrop. 22, 163 (1964).
Chatterjea, J. B.: Haemoglobinopathies in India. J. Indian med. Ass. 34, 102 (1960).
—: Some aspects of haemoglobin E and its genetic interaction with thalassaemia. Indian J. med. Res. 53, 377 (1965).
—, T. Saha, R. Ray, and N. Chaudhury: Response of tropical splenomegaly and thalassaemia to induced malaria. Bull. Calcutta Sch. trop. Med. 4, 105 (1956).
Chernoff, A. I., V. Minnich, and S. Chongcharoensuk: Hemoglobin E, a hereditary abnormality of human hemoglobin. Science 120, 605 (1954).
—, S. Nanakorn, S. Tuchinda, Ch. Kashemsanit, and R. R. Chernoff: Studies on hemoglobin E:I. The clinical, hematologic, and genetic characteristics of the hemoglobin E syndromes. J. Lab. clin. Med. 47, 455 (1956).
Coedes, G.: Les états hindouisés d'Indochine et d'Indonésie. Paris: St. Sulpice 1948.
Colbourne, M. J., E. W. Ikin, A. E. Mourant, H. Lehmann, and H. Thein: Haemoglobin E and the Diego blood group antigen in Sarawak and Burma. Nature (Lond.) 181, 119 (1958).
Curtain, C. C.: A structural study of abnormal haemoglobins occurring in New Guinea. Aust. J. exp. Biol. med. Sci. 42, 89–97 (1964).
—: C. Kidson, D. C. Gajdusek, and J. G. Gorman: Distribution pattern, population genetics, and anthropologic significance of thalassaemia and abnormal hemoglobins ins Melanesia. Amer. J. Phys. Anthrop. 20, 475–483 (1962).
Desilva, C., J. H. P. Jonxis, and R. L. Wickremashinge: Hemoglobin E in Ceylon. in: Abnormal Haemoglobins, Symposium, Istanbul 1957, Oxford: Blackwell 1959.
Detraverse, M. P., C. Lexuan, and E. M. Coquelet: Les hemoglobinpathies au Vietnam. Proc. 7th Congr. Europ. Soc. Haemat., London 1959, Vol. 2, S. 1053. Basel: Karger.
Dormandy, K., S. Lock, and H. Lehmann: Haemoglobin-Q-alpha-thalassaemia. Brit. med. J. 1961/I, 1582.
Eickstedt, E. v.: Rassendynamik von Ostasien, China und Japan, Tai und Kmer, von der Urzeit bis heute. Berlin: de-Gruyter 1944.
Ettinger, E.: Thalassaemia major. Wien. klin. Wschr. 65, 989 (1953).
Elyles, D., R. Wharton, W. Cheong, and M. Warren. Studies on malaria and Anopheles balabacensis in Cambodia. Bull. Wld Hlth Org. 30, 7 (1964).
Firschein, L. I.: Population dynamics of the sickle-cell trait in the Black Caribs of British Honduras. Amer. J. hum. Genet. 13, 233 (1961).
Fisher, C. A.: South-East Asia. A social, economic and political geography. London: Methuen 1964.
Flatz, G.: The Mrabri: Anthropometric, genetic and medical examinations. J. Siam. Society (Bangkok) 51, 161 (1963).
—, H. Hauke, u. E. Kleihauer: Thalassaemia major in Deutschland. Klin. Wschr. 42, 850 (1964).
Flatz, G., C. Pik, and B. Sundharagiati: Malaria and Hemoglobin E in Thailand. Lancet 1964/II, 385.
—, and S. Sringam: Haemoglobinpathies in Thailand. I. A study of families of patients affected with the thalassaemia syndrome. Brit. J. Haemat. 11, 216 (1965a).
—: Haemoglobin E and β-thalassaemia: their distribution in Thailand. Ann. hum. Genet. 29, 151 (1965b).
Flatz, G., and S. Sringam: Malaria and glucose-6-phosphate dehydrogenase deficiency in Thailand. Lancet 1963/II, 1248.
—: Glucose-6-phosphate dehydrogenase deficiency in different ethnic groups in Thailand. Ann. hum. Genet. 23, 315 (1964).
Foote, R., and F. Cook. Mosquitoes of medical importance. Washington: U.S. Dept. of Agriculture 1959.
Frota-Pessoa, O., and A. Wajntal: Mutation rates of abnormal hemoglobin genes. Amer. J. hum. Genet. 15, 123 (1963).
Gabuzda, T., D. Nathan, and F. Gardner: Thalassaemia trait. Genetic combinations of increased fetal and A2 hemoglobins. New Engl. J. Med. 270, 1212 (1964).
Gouttas, A., H. Tseverinis, C. Rombos, A. Paraspyrou et M. Garidi: Hémoglobinose E en Gréce. Sang 31, 1 (1960).
Graff, J. A., E. W. Ikin, H. Lehmann, A. E. Mourant, D. M. Parkin, and R. L. Wickremasinghe: Haemoglobin E and blood groups in the Weddas. J. Physiol. (Lond.) 127, 41 P. (1955).
Graser, E.: Erythroblastenanaemie Typ Cooley bei einem deutschen Kind. Z. Kinderheilk. 62, 698 (1941).
Hall, D. G. E.: A history of south-east Asia. London: McMillan 1964.
Heangsun, S.: Hémoglobine E au Cambodge. Ecole Francaise d'Extrème Orient. Paris: Maisonneuve 1958.
van Heekeren, H. R.: The stone age of Indonesia. s'Gravenshage: Nijhoff 1957.
Heine-Geldern, R.: Urheimat und früheste Wanderungen der Austronesier. Anthropos 27, 231 (1932).
Heller, P., H. Weinstein, V. Yakulis, and I. Rosenthal: Hemoglobin M Kanakee, a new variant of hemoglobin M. Blood 20, 287 (1962).
—, V. Yakulis, A. Rosenzweig, C. Abildgaard, and D. Rucknagel: Mild homozygous beta-thalassaemia. Ann. intern. Med. 64, 52 (1966).
Hoerman, K. C., K. Kamel, and A. Y. Awny: Haemoglobin E in Egypt. Nature (Lond.) 189, 69 (1961).
Horsfall, W., and H. Lehmann: Abnormal haemoglobin in Australian aborigines. Nature (Lond.) 177, 41 (1956).
Huehns, E., and E. Shooter: Human baemoglobins. J. med. Genet. 2, 48 (1965).
Hunt, J. A., and V. W. Ingram: Human haemoglobin E: the chemical effect of gene mutation Nature (Lond.) 184, 870–872 (1959).
—: Abnormal human haemoglobins: VI. The chemical difference between haemoglobin A and E. Biochim. biophys. Acta (Amst.) 49, 520 (1961).
Ingram, V., and A. Stretton: Genetic basis of the thalassaemia diseases. Ann. N.Y. Acad. Sci. 184, 1903 (1959).
Itano, A. H., W. R. Bergren, and P. Sturgeon: Identification of the 4th abnormal human hemoglobin. J. Amer. chem. Soc. 76, 2278 (1954).
Itano, A. H., P. Sturgeon, and W. R. Bergren: Clinical manifestations of inherited abnormal hemoglobins; interaction of hemoglobin E and thalassaemia trait. Blood 10, 396 (1955).
Jackson, F. S., H. Lehmann, and A. Sharih: Thalassaemia in a Tibetan discovered during a haemoglobin survey among the Sherpa. Nature (Lond.) 188, 1121 (1960).
Jonxis, J. H. P., T. Huisman, G. J. Dacosta, and D. Metselaar: Absence of abnormal haemoglobins in some groups of the Papua population of Dutch New Guinea. Nature (Lond.) 181, 1279 (1958).
—, P. V. Schaaf, and H. K. Prins: Amino-acid composition of haemoglobin E. Nature (Lond.) 177, 627 (1956).
Josephson, A. M., H. Weinstein, V. Yakulis, L. Singer, and P. Heller: A new variant of hemoglobin M disease: hemoglobin M Chicago. J. Lab. clin. Med. 59, 918 (1962).
Kaars-Sijpestijn, J. A.: Eenige vormen van erfelijke nietspherocytaire anaemie bij Kinderen. Groningen: Oppenheim 1958.
Kimura, M.: Rules for testing stability of a selective polymorphism. Proc. nat. Acad. Sci. (Wash.) 42, 336 (1956).
Kochhar, B. R., and P. M. Kathpalia: Hemoglobin-E-thalassaemia disease. Indian J. med. Sci. 14, 138–142 (1963).
Kruatrachue, M.: Annual report of the Faculty of Tropical Medicine, University of the Medical Sciences, Bangkok, Dept. of Entomology, 1965.
Kruatrachue, M., S. Nanakorn, and P. Charoenlap: Trophozoite-induced malaria in haemoglobinpathies. proc. 8th Int. Congr. Haemat., Tokyo 1960.
— and L. Suwanakul: Haemoglobin E and Malaria in South-East Thailand. Ann. trop. Med. Parasit. 55, 468 (1961).
Lambotte-Legrand, J., et C. Lambotte-Legrand: L'anémie à hématies falcifomes chez l'enfant indigéne du Bas-Congo. Mem. Inst. Roy. Colon. Belg., 19, 1 (1951).
Lehmann, H.: Variations in human haemoglobin and factors governing their inheritance. Brit. med. Bull. 15, 40 (1959).
—, and R. B. Singh: HbE in Malaya. Nature (Lond.) 178, 696 (1956).
Lehmann, H., P. Story, and H. Thein: Haemoglobin E in Burmese. Brit. med. J. 1956/I, 544.
Li, C. C.: Population genetics. Chicago-London: The University of Chicago Press 1955a.
—: The stability of an equilibrium and the average fitness of a population. Amer. Natur. 89, 281 (1955b).
Lie-Injo, L. E.: Pathological haemoglobins in Indonesia. in: Abnormal haemoglobins, Symposium, Istanbul 1957. Oxford: Blackwell 1959.
—: Haemoglobinopathies in east Asia. Ann. hum. Genet. 28, 101 (1964).
—, and J. Chin: Abnormal haemoglobins and Glucose-6-phosphate dehydrogenase deficiency in Malayan aborigines. Nature (Lond.) 204, 291–292 (1964).
—, S. T. Ho, and K. L. Kho: A case of haemoglobin-E-thalassaemia disease complicated by pregnancy. Acta haemat. (Basel) 22, 194 (1959a).
—, L. K. Kho, D. L. Liem, and O. B. Oei: Further cases of Cooley's anemia in Indonesia. Acta haemat. (Basel) 21, 102 (1959b).
Lie-Injo, L. E. and G. T. Oey: Homozygous haemoglobin E disease in Indonesia. Lancet 1957/I, 20.
Livingstone, F. B.: Balancing human hemoglobin polymorphisms. Hum. Biol. 33, 205 (1961).
— The orign of the sickle-cell gene. Conference on African Historical Anthropology. Chicago: Northwestern University 1962.
—: Aspects of the population dynamics of the abnormal hemoglobin and glucose-6-phosphate dehydrogenase deficiency genes. Amer. J. hum. Genet. 16, 435 (1964).
Loofs, H. H.: Südostasiens Fundamente. Berlin: Safari 1964.
Luce, G. H.: Rice and Religion. J. Siam Soc. (Bangkok) 53, 139 (1965).
Mandel, S. P.: The stability of amultiple allelic system. Heredity 13, 289 (1959).
Marks, P., E. Burka, and R. Rifkind: Control of protein synthesis in reticulocytes and the formation of hemoglobin A and F in thalassaemia syndromes and other hemolytic anemias. Medicine (Baltimore) 43, 769 (1964).
Mathur, K. S., T. N. Mehrotra, R. S. Dayal, and S. N. Yadav: Indicence of haemoglobin E and thalassaemia in Uttar Pradesh. J. Indian med. Ass. 39, 172–177 (1962).
McFadzean, A. J., and D. Todd: The distribution of Cooley's anaemia in China. Trans. roy. Soc. trop. Med. Hyg. 58, 490 (1964).
Minnich, V., S. Nanakorn, S. Chong-Charoensuk, and S. Kochaseni: Mediterranean Anemia. A study of thirty two cases in Thailand. Blood 9, 1 (1954).
Motulsky, A. G.: Hereditary red cell traits and malaria. Amer. J. trop. Med. Hyg. 13, 147 (1964a).
—: Current concepts of the genetics of thalassaemia. Cold Spr. Harb. Symp. quant. Biol. 29, 150 (1964b).
—, T. C. Lee, and G. R. Fraser: Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, thalassaemia and abnormal haemoglobins in Taiwan. J. med. Genet. 2, 18 (1965).
—, E. Stransky, and G. R. Fraser: Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, thalassaemia and abnormal haemoglobins in the Philippines. J. med. Genet. 1, 102 (1963).
Nagaratnam, N., R. L. Wickremasinghe, U. S. Jayawickreme, and V. S. Maheson: Haemoglobin-E-syndromes in a Ceylonese family. Brit. med. J. 1958/I, 866.
Nanakorn, S.: Haemoglobinopathies in Thailand. In: Abnormal haemoglobins. C.I.O.M.S. Symposion, Istanbul 1957. Oxford: Blackwell Publ. 1959.
—, and V. Minnich: Studies on hemoglobin E. III. Homozygous hemoglobin E and variants of hemoglobin E and thalassaemia. A family study. Blood 12, 529 (1957).
—, and A. I. Chernoff: Studies on hemoglobin E. II. The indicence of hemoglobin E in Thailand. J. Lab. clin. Med. 47, 490 (1956).
Nijenhuis, L. E.: Blood group frequencies and haemoglobin types in Tibetans and Nepalese. Vox. Sang. (Basel) 8, 622 (1963).
Nirenberg, M., P. Leder, M. Bernfield, R. Brimacombe, J. Turpin, F. Rottman, and C. O'Neal: RNA codewords and protein synthesis VII. On the general nature of the RNA code. Proc. Nat. Acad. Sci. (Wash.) 53, 1161 (1965).
Okcuoglu, A., V. Minnich, and A. Arcasoy: A further example of thalassaemia-hemoglobin E disease in Turkey. Acta haemat. (Basel) 34, 354 (1965).
Pearson, H. A., and M. Moore: Human hemoglobin gene linkage: report of a family with hemoglobin B2, hemoglobin S, and β-thalassaemia, including a probable crossover between thalassaemia and delta loci. Amer. J. hum. Genet. 17, 125 (1965).
Penrose, L. S.: Natural selection in man: some basic problems, in: Natural selection in human populations. London: Pergamon Press 1959.
—, S. M. Smith, and D. A. Sprott: On the stability of allelic systems with special reference to haemoglobins A, S and C. Ann. hum. Genet. 21, 90 (1956).
Perabo, F.: Über das Vorkommen von Cooley-Anämie in Burma. Helv. paediat. Acta 9, 339 (1954).
Prout, T.: The estimation of fitnesses from gentopypic frequencies. Evolution 19, 546 (1965).
Punt, K., and J. Vangool: Thalassaemia-haemoglobin-E-disease in two Indo-european boys. Acta haemat. (Basel) 17, 305 (1957).
Ray, R. N., J. Chatterjea, and R. Chaudhuri: Observations on the resistance in HbE thalassaemia disease to induced infection with Plasmodium vivax. Bull. Wld Hlth Org. 30, 51 (1964).
Rucknagel, D. L.: Current concepts of the genetics of thalassaemia. Ann. N.Y. Acad. Sci. 119, 436 (1964).
—, and J. Neel: The hemoglobinopathies. Progr. med. Genet. 1, 158 (1961).
Ryan, B. P.: Thalassaemia major in New Guinea. Med. J. Aust. 38, 753 (1961).
Sahawi, E., H. Hunger u. K. Betke: Sporadisches Auftreten von HbM (Boston-Typ?) in einer mitteldeutschen Familie. Schweiz. med. Wschr. 92, 1090 (1962).
Sanghvi, L. D.: Genetic diversity in the people of Western India. Eugen. Quart 1, 235 (1954).
Sangvichien, S.: A preliminary report on non-metrical characteristics of neolithic skeletons found at Bankhao, Kanchanaburi. J. Siam. Soc. (Bangkok) 54, 1 (1966).
Schmidt, W.: Die Mon-Khmer-Völker. Ein Bindeglied zwischen den Völkern Zentralasiens und Austronesiens. Braunschweig: Vieweg 1906.
Shahid, M., G. Abuhaydar, and N. Abuhaydar: Thalassaemia-haemoglobin-E-disease: a case report from Qatar (Persian Gulf). Man (Lond.) 63, 129 (1963).
Shibata, S.: Hemoglobinopathy, with special reference to the abnormal hemoglobins found in Japan. Acta haemat. jap. 24, 141 (1961).
Singer, R., O. E. Budtz-Olsen, P. Brain, and J. Saugrain: Physical features, sickling and serology of the Malagassy of Madagascar. Amer. J. phys. Anthrop. 15, 91 (1957).
Smith, S. M.: Notes on sickle cell polymorphism; appendix. Ann. hum. Genet. 19, 51 (1954).
Stammatoyannopoulos, G., and Ph. Fessas: Thalassaemia, Glucose-6-phosphate dehydrogenase deficiency, sickling and malarial endemicity in Greece: a study of five areas. Brit. med. J. 1964/I, 875.
Stransky, E.: Haemoglobin E. Brit. med. J. 1956/I, 1300.
—: On hemoglobin E disease in the Philippines. Acta haemat. jap. 21, Suppl. I, 218 (1958).
Sundharagiati, B.: Blood disorders in different parts of the country. A study of 2.800 specimens of blood. Med. J. Dept. med. Serv. (Bangkok) 6, 3 (1957).
—, and D. Viseshakul: Paperelectrophoretic studies on HgbE in the people of Northeast Thailand. Med. J. Dept. Med. Serv. (Bangkok) 7, 411 (1958).
—: Electrophoretic studies on HgbE in the people of Central Thailand. Med. J. Dept. Med. Serv. 8, 397 (1959a).
—: Electrophoretic studies on HgbE in the people of Northern Thailand. Med. J. Dept. Med. Serv. (Bangkok) 8, 388 (1959b).
Swarup, S., S. K. Gosh, and J. B. Chatterjea: Haemoglobin E disease in Bengalees. J. Indian med. Ass. 35, 13 (1960).
—: Effect of iron deficiency on the relative rates of synthesis of haemoglobin A and haemoglobin E as studied in a HbE heterozygote. Bull. Calcutta Sch. trop. Med. 13, 7 (1965).
Thepusdin, C., B. Blackwell, J. Huang, and R. Blackwell: Comparison of the distribution of haptoglobin and hemoglobin types in a Thai population. Israel J. med. Sci. 1, 768 (1965).
Tuchinda, S., D. Rucknagel, V. Minnich, U. Boonyaprakob, K. Balankura, and V. Suvatee: The coexistence of genes of hemoglobin E and α-thalassaemia in Thais, with resulting suppression of hemoglobin E synthesis. Amer. J. hum. Genet. 16, 311 (1964).
—, C. Vareenil, P. Bhanchit, and V. Minnich: Fast hemoglobin component found in umbilical-cord blood of Thai babies. Pediatrics 24, 43 (1959).
Vandepitte, J. M., W. W. Zuelzer, J. V. Neel, and J. Colaert: Evidence concerning the inadequacy of mutation as an explanation of the frequency of the sickle-cell gene in the Belgian Congo. Blood 10, 341 (1955).
Vella, F.: Hereditary abnormalities in human haemoglobin synthesis. Proc. Cent. Bicent. Congr. Biol., Singapore 1958 (a), p. 193.
—: The incidence of abnormal haemoglobin variants in Singapore and Malaya. Indian J. Child. Hlth 13, 804 (1958b).
—: Abnormal haemoglobin variants in 10,441 Chinese subjects. Acta haemat. jap. 23, 393 (1960).
—, and P. S. Raman: Search for abnormal hemoglobins at the Johore Baru General Hospital —three cases of presumed hemoglobin E disease. Proc. Alumini Ass. Malaya 12, 97 (1959).
— and D. Tavaria: Haemoglobin variants in Sarawak and North-Borneo. Nature (Lond.) 190, 729 (1961).
Vogel, F., und G. Röhrborn: Mutationsvorgänge bei der Entstehung von Hämoglobinvarianten. Humangenetik 1, 635 (1965).
— u. D. Strobel: Über die Populationsgenetik der AB0-Blutgruppen. I. Mitteilung. Mathematische Blutgruppen-Selektionsmodelle. Acta genet. (Basel) 10, 27 (1960).
Wasi, P., S. Nanakorn, and A. Suingdumrong: Studies on the distribution of haemoglobin E, thalassaemias and G-6-PD deficiency in northeastern Thailand. Nature (Lond.) (in print).
Weatherall, D. J.: The Thalassaemia syndromes. Oxford: Blackwell Sci. Publ. 1965.
—, and M. Naughton: Globin synthesis in thalassaemia. J. clin. Invest. 44, 1108 (1965).
Wickremasinghe, R. L., E. W. Ikin, A. E. Mourant, and H. Lehmann: The blood groups and the haemoglobins of the Veddah in Ceylon. J. Roy. anthrop. Inst. 93, 117 (1963).
Wood, W. A. R.: A history of Siam. Bangkok: Chalermnit 1924.
Zuckerkandl, E.: Controller gene diseases: the operon model as applied to β-thalassaemia, familial fetal hemoglobinemia and the normal switch from the production of fetal hemoglobin to that of adult hemoglobin. J. molec. Biol. 8, 128 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Flatz, G. Hemoglobin E: Distribution and population dynamics. Hum Genet 3, 189–234 (1967). https://doi.org/10.1007/BF00273124
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00273124